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CERS4 | ceramide synthase 4; May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity) (394 aa) | |||
WDR76 | WD repeat domain 76 (626 aa) | |||
NPC1L1 | NPC1-like 1; Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorbtion. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down- regulates its expression and secretion by inhibiting its maturation and accelerating [...] (1359 aa) | |||
UBB | ubiquitin B (229 aa) | |||
UBC | ubiquitin C (685 aa) | |||
LGR4 | leucine-rich repeat containing G protein-coupled receptor 4; Orphan receptor (951 aa) |