13 items (Homo sapiens) - STRING network view

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Input:
	IL10RA	interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity (578 aa)
	UCN2	urocortin 2; Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress (112 aa)
	IL10RB	interleukin 10 receptor, beta; Shared cell surface receptor required for the activation of five class 2 cytokines- IL10, IL22, IL26, IL28, and IFNL1 (325 aa)
	IL28RA	interleukin 28 receptor, alpha (interferon, lambda receptor); The IFNLR1/IL10RB dimer is a receptor for IFNL1, IFNL2 and IFNL3. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium (520 aa)
	IL22	interleukin 22; Cytokine that contributes to the inflammatory response in vivo (179 aa)
	IL29	interleukin 29 (interferon, lambda 1); Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway (200 aa)
	IL28A	interleukin 28A (interferon, lambda 2); Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the [...] (200 aa)
	JAK1	Janus kinase 1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor (1154 aa)
	UBC	ubiquitin C (685 aa)
	MAP3K5	mitogen-activated protein kinase kinase kinase 5; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Me [...] (1374 aa)
	UCN3	urocortin 3 (161 aa)
	IL28B	interleukin 28B (interferon, lambda 3); Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the [...] (196 aa)
	IL10	interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells (178 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL10	IL10RA	ENSP00000412237	ENSP00000227752	interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells	interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity	0.999
IL10	IL10RB	ENSP00000412237	ENSP00000290200	interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells	interleukin 10 receptor, beta; Shared cell surface receptor required for the activation of five class 2 cytokines- IL10, IL22, IL26, IL28, and IFNL1	0.991
IL10	IL22	ENSP00000412237	ENSP00000329384	interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells	interleukin 22; Cytokine that contributes to the inflammatory response in vivo	0.583
IL10	IL28RA	ENSP00000412237	ENSP00000327824	interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells	interleukin 28 receptor, alpha (interferon, lambda receptor); The IFNLR1/IL10RB dimer is a receptor for IFNL1, IFNL2 and IFNL3. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium	0.851
IL10	IL29	ENSP00000412237	ENSP00000329991	interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells	interleukin 29 (interferon, lambda 1); Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway	0.416
IL10	JAK1	ENSP00000412237	ENSP00000343204	interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells	Janus kinase 1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor	0.952
IL10	MAP3K5	ENSP00000412237	ENSP00000351908	interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells	mitogen-activated protein kinase kinase kinase 5; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Me [...]	0.912
IL10	UBC	ENSP00000412237	ENSP00000344818	interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells	ubiquitin C	0.829
IL10RA	IL10	ENSP00000227752	ENSP00000412237	interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity	interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells	0.999
IL10RA	IL10RB	ENSP00000227752	ENSP00000290200	interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity	interleukin 10 receptor, beta; Shared cell surface receptor required for the activation of five class 2 cytokines- IL10, IL22, IL26, IL28, and IFNL1	0.991
IL10RA	IL22	ENSP00000227752	ENSP00000329384	interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity	interleukin 22; Cytokine that contributes to the inflammatory response in vivo	0.948
IL10RA	IL28A	ENSP00000227752	ENSP00000333639	interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity	interleukin 28A (interferon, lambda 2); Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the [...]	0.874
IL10RA	IL28B	ENSP00000227752	ENSP00000409000	interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity	interleukin 28B (interferon, lambda 3); Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the [...]	0.862
IL10RA	IL28RA	ENSP00000227752	ENSP00000327824	interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity	interleukin 28 receptor, alpha (interferon, lambda receptor); The IFNLR1/IL10RB dimer is a receptor for IFNL1, IFNL2 and IFNL3. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium	0.502
IL10RA	IL29	ENSP00000227752	ENSP00000329991	interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity	interleukin 29 (interferon, lambda 1); Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway	0.886
IL10RA	JAK1	ENSP00000227752	ENSP00000343204	interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity	Janus kinase 1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor	0.996
IL10RA	MAP3K5	ENSP00000227752	ENSP00000351908	interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity	mitogen-activated protein kinase kinase kinase 5; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Me [...]	0.900
IL10RA	UBC	ENSP00000227752	ENSP00000344818	interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity	ubiquitin C	0.576
IL10RB	IL10	ENSP00000290200	ENSP00000412237	interleukin 10 receptor, beta; Shared cell surface receptor required for the activation of five class 2 cytokines- IL10, IL22, IL26, IL28, and IFNL1	interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells	0.991
IL10RB	IL10RA	ENSP00000290200	ENSP00000227752	interleukin 10 receptor, beta; Shared cell surface receptor required for the activation of five class 2 cytokines- IL10, IL22, IL26, IL28, and IFNL1	interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity	0.991

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