node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IL10 | IL10RA | ENSP00000412237 | ENSP00000227752 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity | 0.999 |
IL10 | IL10RB | ENSP00000412237 | ENSP00000290200 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | interleukin 10 receptor, beta; Shared cell surface receptor required for the activation of five class 2 cytokines- IL10, IL22, IL26, IL28, and IFNL1 | 0.991 |
IL10 | IL22 | ENSP00000412237 | ENSP00000329384 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | interleukin 22; Cytokine that contributes to the inflammatory response in vivo | 0.583 |
IL10 | IL28RA | ENSP00000412237 | ENSP00000327824 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | interleukin 28 receptor, alpha (interferon, lambda receptor); The IFNLR1/IL10RB dimer is a receptor for IFNL1, IFNL2 and IFNL3. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium | 0.851 |
IL10 | IL29 | ENSP00000412237 | ENSP00000329991 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | interleukin 29 (interferon, lambda 1); Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway | 0.416 |
IL10 | JAK1 | ENSP00000412237 | ENSP00000343204 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | Janus kinase 1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor | 0.952 |
IL10 | MAP3K5 | ENSP00000412237 | ENSP00000351908 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | mitogen-activated protein kinase kinase kinase 5; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Me [...] | 0.912 |
IL10 | UBC | ENSP00000412237 | ENSP00000344818 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | ubiquitin C | 0.829 |
IL10RA | IL10 | ENSP00000227752 | ENSP00000412237 | interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | 0.999 |
IL10RA | IL10RB | ENSP00000227752 | ENSP00000290200 | interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity | interleukin 10 receptor, beta; Shared cell surface receptor required for the activation of five class 2 cytokines- IL10, IL22, IL26, IL28, and IFNL1 | 0.991 |
IL10RA | IL22 | ENSP00000227752 | ENSP00000329384 | interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity | interleukin 22; Cytokine that contributes to the inflammatory response in vivo | 0.948 |
IL10RA | IL28A | ENSP00000227752 | ENSP00000333639 | interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity | interleukin 28A (interferon, lambda 2); Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the [...] | 0.874 |
IL10RA | IL28B | ENSP00000227752 | ENSP00000409000 | interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity | interleukin 28B (interferon, lambda 3); Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the [...] | 0.862 |
IL10RA | IL28RA | ENSP00000227752 | ENSP00000327824 | interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity | interleukin 28 receptor, alpha (interferon, lambda receptor); The IFNLR1/IL10RB dimer is a receptor for IFNL1, IFNL2 and IFNL3. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium | 0.502 |
IL10RA | IL29 | ENSP00000227752 | ENSP00000329991 | interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity | interleukin 29 (interferon, lambda 1); Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway | 0.886 |
IL10RA | JAK1 | ENSP00000227752 | ENSP00000343204 | interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity | Janus kinase 1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor | 0.996 |
IL10RA | MAP3K5 | ENSP00000227752 | ENSP00000351908 | interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity | mitogen-activated protein kinase kinase kinase 5; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Me [...] | 0.900 |
IL10RA | UBC | ENSP00000227752 | ENSP00000344818 | interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity | ubiquitin C | 0.576 |
IL10RB | IL10 | ENSP00000290200 | ENSP00000412237 | interleukin 10 receptor, beta; Shared cell surface receptor required for the activation of five class 2 cytokines- IL10, IL22, IL26, IL28, and IFNL1 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | 0.991 |
IL10RB | IL10RA | ENSP00000290200 | ENSP00000227752 | interleukin 10 receptor, beta; Shared cell surface receptor required for the activation of five class 2 cytokines- IL10, IL22, IL26, IL28, and IFNL1 | interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity | 0.991 |