7 items (Homo sapiens) - STRING network view

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Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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protein of unknown 3D structure

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

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Your Input:
	CRY1	cryptochrome 1 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL (586 aa)
	BHLHE41	basic helix-loop-helix family, member e41; May be a transcriptional repressor that represses both basal and activated transcription (482 aa)
	PER2	period homolog 2 (Drosophila); Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK\|NPAS2-BMAL1\|BMAL2-induced transactivation (By similarity) (1255 aa)
	ARNTL2	aryl hydrocarbon receptor nuclear translocator-like 2 (636 aa)
	C1orf51	chromosome 1 open reading frame 51 (385 aa)
	ARNTL	aryl hydrocarbon receptor nuclear translocator-like (625 aa)
	CRY2	cryptochrome 2 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL (614 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARNTL	BHLHE41	ENSP00000374357	ENSP00000242728	aryl hydrocarbon receptor nuclear translocator-like	basic helix-loop-helix family, member e41; May be a transcriptional repressor that represses both basal and activated transcription	0.976
ARNTL	CRY1	ENSP00000374357	ENSP00000008527	aryl hydrocarbon receptor nuclear translocator-like	cryptochrome 1 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL	0.999
ARNTL	CRY2	ENSP00000374357	ENSP00000406751	aryl hydrocarbon receptor nuclear translocator-like	cryptochrome 2 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL	0.999
ARNTL	PER2	ENSP00000374357	ENSP00000254657	aryl hydrocarbon receptor nuclear translocator-like	period homolog 2 (Drosophila); Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK\|NPAS2-BMAL1\|BMAL2-induced transactivation (By similarity)	0.997
ARNTL2	BHLHE41	ENSP00000266503	ENSP00000242728	aryl hydrocarbon receptor nuclear translocator-like 2	basic helix-loop-helix family, member e41; May be a transcriptional repressor that represses both basal and activated transcription	0.433
ARNTL2	CRY1	ENSP00000266503	ENSP00000008527	aryl hydrocarbon receptor nuclear translocator-like 2	cryptochrome 1 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL	0.847
ARNTL2	CRY2	ENSP00000266503	ENSP00000406751	aryl hydrocarbon receptor nuclear translocator-like 2	cryptochrome 2 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL	0.851
ARNTL2	PER2	ENSP00000266503	ENSP00000254657	aryl hydrocarbon receptor nuclear translocator-like 2	period homolog 2 (Drosophila); Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK\|NPAS2-BMAL1\|BMAL2-induced transactivation (By similarity)	0.774
BHLHE41	ARNTL	ENSP00000242728	ENSP00000374357	basic helix-loop-helix family, member e41; May be a transcriptional repressor that represses both basal and activated transcription	aryl hydrocarbon receptor nuclear translocator-like	0.976
BHLHE41	ARNTL2	ENSP00000242728	ENSP00000266503	basic helix-loop-helix family, member e41; May be a transcriptional repressor that represses both basal and activated transcription	aryl hydrocarbon receptor nuclear translocator-like 2	0.433
BHLHE41	C1orf51	ENSP00000242728	ENSP00000290363	basic helix-loop-helix family, member e41; May be a transcriptional repressor that represses both basal and activated transcription	chromosome 1 open reading frame 51	0.576
BHLHE41	CRY1	ENSP00000242728	ENSP00000008527	basic helix-loop-helix family, member e41; May be a transcriptional repressor that represses both basal and activated transcription	cryptochrome 1 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL	0.989
BHLHE41	CRY2	ENSP00000242728	ENSP00000406751	basic helix-loop-helix family, member e41; May be a transcriptional repressor that represses both basal and activated transcription	cryptochrome 2 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL	0.982
BHLHE41	PER2	ENSP00000242728	ENSP00000254657	basic helix-loop-helix family, member e41; May be a transcriptional repressor that represses both basal and activated transcription	period homolog 2 (Drosophila); Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK\|NPAS2-BMAL1\|BMAL2-induced transactivation (By similarity)	0.989
C1orf51	BHLHE41	ENSP00000290363	ENSP00000242728	chromosome 1 open reading frame 51	basic helix-loop-helix family, member e41; May be a transcriptional repressor that represses both basal and activated transcription	0.576
CRY1	ARNTL	ENSP00000008527	ENSP00000374357	cryptochrome 1 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL	aryl hydrocarbon receptor nuclear translocator-like	0.999
CRY1	ARNTL2	ENSP00000008527	ENSP00000266503	cryptochrome 1 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL	aryl hydrocarbon receptor nuclear translocator-like 2	0.847
CRY1	BHLHE41	ENSP00000008527	ENSP00000242728	cryptochrome 1 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL	basic helix-loop-helix family, member e41; May be a transcriptional repressor that represses both basal and activated transcription	0.989
CRY1	CRY2	ENSP00000008527	ENSP00000406751	cryptochrome 1 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL	cryptochrome 2 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL	0.995
CRY1	PER2	ENSP00000008527	ENSP00000254657	cryptochrome 1 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL	period homolog 2 (Drosophila); Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK\|NPAS2-BMAL1\|BMAL2-induced transactivation (By similarity)	0.999

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