| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARRB1 | GNAI1 | ENSP00000409581 | ENSP00000343027 | arrestin, beta 1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and re [...] | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.444 |
| ARRB1 | GPR50 | ENSP00000409581 | ENSP00000218316 | arrestin, beta 1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and re [...] | G protein-coupled receptor 50; Does not bind melatonin | 0.743 |
| ARRB1 | MT1A | ENSP00000409581 | ENSP00000290705 | arrestin, beta 1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and re [...] | metallothionein 1A; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids | 0.570 |
| ARRB1 | TP53 | ENSP00000409581 | ENSP00000269305 | arrestin, beta 1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and re [...] | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.644 |
| ARRB1 | UBC | ENSP00000409581 | ENSP00000344818 | arrestin, beta 1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and re [...] | ubiquitin C | 0.980 |
| GNAI1 | ARRB1 | ENSP00000343027 | ENSP00000409581 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | arrestin, beta 1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and re [...] | 0.444 |
| GNAI1 | GPR50 | ENSP00000343027 | ENSP00000218316 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | G protein-coupled receptor 50; Does not bind melatonin | 0.626 |
| GNAI1 | MT1A | ENSP00000343027 | ENSP00000290705 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | metallothionein 1A; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids | 0.570 |
| GNAI1 | UBC | ENSP00000343027 | ENSP00000344818 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | ubiquitin C | 0.928 |
| GPR50 | ARRB1 | ENSP00000218316 | ENSP00000409581 | G protein-coupled receptor 50; Does not bind melatonin | arrestin, beta 1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and re [...] | 0.743 |
| GPR50 | GNAI1 | ENSP00000218316 | ENSP00000343027 | G protein-coupled receptor 50; Does not bind melatonin | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.626 |
| GPR50 | MT1A | ENSP00000218316 | ENSP00000290705 | G protein-coupled receptor 50; Does not bind melatonin | metallothionein 1A; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids | 0.622 |
| LAGE3 | MT1A | ENSP00000349923 | ENSP00000290705 | L antigen family, member 3 | metallothionein 1A; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids | 0.644 |
| LAGE3 | UBC | ENSP00000349923 | ENSP00000344818 | L antigen family, member 3 | ubiquitin C | 0.925 |
| MT1A | ARRB1 | ENSP00000290705 | ENSP00000409581 | metallothionein 1A; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids | arrestin, beta 1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and re [...] | 0.570 |
| MT1A | GNAI1 | ENSP00000290705 | ENSP00000343027 | metallothionein 1A; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.570 |
| MT1A | GPR50 | ENSP00000290705 | ENSP00000218316 | metallothionein 1A; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids | G protein-coupled receptor 50; Does not bind melatonin | 0.622 |
| MT1A | LAGE3 | ENSP00000290705 | ENSP00000349923 | metallothionein 1A; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids | L antigen family, member 3 | 0.644 |
| MT1A | TP53 | ENSP00000290705 | ENSP00000269305 | metallothionein 1A; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.629 |
| TNF | TP53 | ENSP00000398698 | ENSP00000269305 | tumor necrosis factor | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.932 |
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