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CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (502 aa) | |||
ALDH3A1 | aldehyde dehydrogenase 3 family, member A1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes (453 aa) | |||
GSTM5 | glutathione S-transferase mu 5; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (218 aa) | |||
MGST2 | microsomal glutathione S-transferase 2; Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4- dinitrobenzene with reduced glutathione (147 aa) | |||
ADH4 | alcohol dehydrogenase 4 (class II), pi polypeptide (380 aa) | |||
GSTA5 | glutathione S-transferase alpha 5 (222 aa) | |||
GSTT2B | glutathione S-transferase theta 2B (gene/pseudogene); Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity (244 aa) | |||
CYP2A6 | cytochrome P450, family 2, subfamily A, polypeptide 6 (494 aa) | |||
ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide (375 aa) | |||
CYP2S1 | cytochrome P450, family 2, subfamily S, polypeptide 1; Has a potential importance for extrahepatic xenobiotic metabolism (504 aa) | |||
GSTM1 | glutathione S-transferase mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (218 aa) | |||
ALDH1A3 | aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) (512 aa) | |||
CYP2A13 | cytochrome P450, family 2, subfamily A, polypeptide 13; Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N- dimethylaniline, 2’-methoxyacetophenone, N- nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity (494 aa) | |||
CYP2F1 | cytochrome P450, family 2, subfamily F, polypeptide 1; May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3- methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine (491 aa) | |||
GSTA1 | glutathione S-transferase alpha 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (222 aa) | |||
GPX4 | glutathione peroxidase 4; Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity) (197 aa) | |||
GPX7 | glutathione peroxidase 7; It protects esophageal epithelia from hydrogen peroxide- induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks (187 aa) | |||
MGST3 | microsomal glutathione S-transferase 3; Also functions as a glutathione peroxidase (152 aa) | |||
GSTM4 | glutathione S-transferase mu 4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Active on 1- chloro-2,4-dinitrobenzene (218 aa) | |||
CYP2C19 | cytochrome P450, family 2, subfamily C, polypeptide 19; Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine (490 aa) | |||
TXNDC12 | thioredoxin domain containing 12 (endoplasmic reticulum); Possesses significant protein thiol-disulfide oxidase activity (172 aa) | |||
GPX3 | glutathione peroxidase 3 (plasma); Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione (226 aa) | |||
GPX2 | glutathione peroxidase 2 (gastrointestinal); Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors (190 aa) | |||
GGT5 | gamma-glutamyltransferase 5; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4) (587 aa) | |||
GSTP1 | glutathione S-transferase pi 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (210 aa) | |||
GGT6 | gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) (493 aa) |