node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHCHD6 | ERLIN1 | ENSP00000290913 | ENSP00000384900 | coiled-coil-helix-coiled-coil-helix domain containing 6; Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption | ER lipid raft associated 1; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) | 0.644 |
CHCHD6 | IMMT | ENSP00000290913 | ENSP00000387262 | coiled-coil-helix-coiled-coil-helix domain containing 6; Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption | inner membrane protein, mitochondrial | 0.914 |
CHCHD6 | MTX2 | ENSP00000290913 | ENSP00000249442 | coiled-coil-helix-coiled-coil-helix domain containing 6; Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption | metaxin 2; Involved in transport of proteins into the mitochondrion | 0.569 |
CHCHD6 | PTPLAD1 | ENSP00000290913 | ENSP00000261875 | coiled-coil-helix-coiled-coil-helix domain containing 6; Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption | protein tyrosine phosphatase-like A domain containing 1 | 0.645 |
CHCHD6 | SAMM50 | ENSP00000290913 | ENSP00000345445 | coiled-coil-helix-coiled-coil-helix domain containing 6; Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption | sorting and assembly machinery component 50 homolog (S. cerevisiae); May be required for the assembly pathway of mitochondrial outer membrane proteins (By similarity) | 0.810 |
CHCHD6 | SLC25A12 | ENSP00000290913 | ENSP00000388658 | coiled-coil-helix-coiled-coil-helix domain containing 6; Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption | solute carrier family 25 (aspartate/glutamate carrier), member 12; Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle | 0.644 |
CHCHD6 | TMED4 | ENSP00000290913 | ENSP00000404042 | coiled-coil-helix-coiled-coil-helix domain containing 6; Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption | transmembrane emp24 protein transport domain containing 4; Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity) | 0.645 |
CHCHD6 | UBC | ENSP00000290913 | ENSP00000344818 | coiled-coil-helix-coiled-coil-helix domain containing 6; Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption | ubiquitin C | 0.495 |
ERLIN1 | CHCHD6 | ENSP00000384900 | ENSP00000290913 | ER lipid raft associated 1; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) | coiled-coil-helix-coiled-coil-helix domain containing 6; Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption | 0.644 |
ERLIN1 | UBC | ENSP00000384900 | ENSP00000344818 | ER lipid raft associated 1; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) | ubiquitin C | 0.858 |
IMMT | CHCHD6 | ENSP00000387262 | ENSP00000290913 | inner membrane protein, mitochondrial | coiled-coil-helix-coiled-coil-helix domain containing 6; Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption | 0.914 |
IMMT | MTX2 | ENSP00000387262 | ENSP00000249442 | inner membrane protein, mitochondrial | metaxin 2; Involved in transport of proteins into the mitochondrion | 0.949 |
IMMT | SAMM50 | ENSP00000387262 | ENSP00000345445 | inner membrane protein, mitochondrial | sorting and assembly machinery component 50 homolog (S. cerevisiae); May be required for the assembly pathway of mitochondrial outer membrane proteins (By similarity) | 0.998 |
MTX2 | CHCHD6 | ENSP00000249442 | ENSP00000290913 | metaxin 2; Involved in transport of proteins into the mitochondrion | coiled-coil-helix-coiled-coil-helix domain containing 6; Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption | 0.569 |
MTX2 | IMMT | ENSP00000249442 | ENSP00000387262 | metaxin 2; Involved in transport of proteins into the mitochondrion | inner membrane protein, mitochondrial | 0.949 |
MTX2 | SAMM50 | ENSP00000249442 | ENSP00000345445 | metaxin 2; Involved in transport of proteins into the mitochondrion | sorting and assembly machinery component 50 homolog (S. cerevisiae); May be required for the assembly pathway of mitochondrial outer membrane proteins (By similarity) | 0.993 |
MTX2 | UBC | ENSP00000249442 | ENSP00000344818 | metaxin 2; Involved in transport of proteins into the mitochondrion | ubiquitin C | 0.483 |
NPM1 | UBC | ENSP00000296930 | ENSP00000344818 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | ubiquitin C | 0.999 |
PPP1CA | UBC | ENSP00000326031 | ENSP00000344818 | protein phosphatase 1, catalytic subunit, alpha isozyme; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent p [...] | ubiquitin C | 0.986 |
PTPLAD1 | CHCHD6 | ENSP00000261875 | ENSP00000290913 | protein tyrosine phosphatase-like A domain containing 1 | coiled-coil-helix-coiled-coil-helix domain containing 6; Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption | 0.645 |