node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCC1 | UBC | ENSP00000382342 | ENSP00000344818 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | ubiquitin C | 0.954 |
AR | CDK2 | ENSP00000363822 | ENSP00000266970 | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and [...] | 0.537 |
AR | NCOR1 | ENSP00000363822 | ENSP00000268712 | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors | 0.999 |
AR | PIP | ENSP00000363822 | ENSP00000291009 | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | prolactin-induced protein | 0.420 |
AR | SHBG | ENSP00000363822 | ENSP00000369816 | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | sex hormone-binding globulin | 0.815 |
AR | UBC | ENSP00000363822 | ENSP00000344818 | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | ubiquitin C | 0.999 |
AZGP1 | B2M | ENSP00000292401 | ENSP00000452780 | alpha-2-glycoprotein 1, zinc-binding; Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | 0.610 |
AZGP1 | CDK19 | ENSP00000292401 | ENSP00000357907 | alpha-2-glycoprotein 1, zinc-binding; Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids | cyclin-dependent kinase 19 | 0.551 |
AZGP1 | GTPBP4 | ENSP00000292401 | ENSP00000354040 | alpha-2-glycoprotein 1, zinc-binding; Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids | GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity) | 0.481 |
AZGP1 | ITGAV | ENSP00000292401 | ENSP00000261023 | alpha-2-glycoprotein 1, zinc-binding; Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids | integrin, alpha V | 0.576 |
AZGP1 | MR1 | ENSP00000292401 | ENSP00000356552 | alpha-2-glycoprotein 1, zinc-binding; Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids | major histocompatibility complex, class I-related | 0.402 |
AZGP1 | PIP | ENSP00000292401 | ENSP00000291009 | alpha-2-glycoprotein 1, zinc-binding; Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids | prolactin-induced protein | 0.939 |
AZGP1 | UBC | ENSP00000292401 | ENSP00000344818 | alpha-2-glycoprotein 1, zinc-binding; Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids | ubiquitin C | 0.491 |
AZGP1 | USP53 | ENSP00000292401 | ENSP00000274030 | alpha-2-glycoprotein 1, zinc-binding; Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids | ubiquitin specific peptidase 53; Has no peptidase activity | 0.740 |
B2M | AZGP1 | ENSP00000452780 | ENSP00000292401 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | alpha-2-glycoprotein 1, zinc-binding; Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids | 0.610 |
B2M | HFE | ENSP00000452780 | ENSP00000417404 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | hemochromatosis | 0.998 |
B2M | HLA-A | ENSP00000452780 | ENSP00000366005 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity) | 0.998 |
B2M | HLA-B | ENSP00000452780 | ENSP00000399168 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity) | 0.999 |
B2M | HLA-C | ENSP00000452780 | ENSP00000365402 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity) | 0.986 |
B2M | HLA-G | ENSP00000452780 | ENSP00000353472 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells | 0.924 |