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KLB | klotho beta; Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity) (1044 aa) | |||
LCT | lactase; LPH splits lactose in the small intestine (1927 aa) | |||
YDJC | YdjC homolog (bacterial) (323 aa) | |||
LCTL | lactase-like (567 aa) | |||
PCMT1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase (285 aa) | |||
KL | klotho; May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity) (1012 aa) | |||
KLRP | glucosidase, beta, acid 3 (cytosolic) (EC-3.2.1.21) (162 aa) | |||
GBA3 | Cytosolic beta-glucosidase ; Glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. Able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens. Possesses beta- glycosylceramidase activity and may be involved in a nonlysosomal catabolic pathway of glycosylceramide (469 aa) |