Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
LRRC40 LRRC40 GP9 GP9 PRTG PRTG CDON CDON DCN DCN LRRIQ4 LRRIQ4 UNC5CL UNC5CL NTN3 NTN3 NEO1 NEO1 LRRC23 LRRC23 LRRN4 LRRN4 UNC5C UNC5C IGDCC3 IGDCC3 DCC DCC LRRC46 LRRC46 FNDC1 FNDC1 UNC5B UNC5B UNC5A UNC5A CHADL CHADL IGDCC4 IGDCC4 UNC5D UNC5D LRRK2 LRRK2 DRAXIN DRAXIN PODN PODN OPTC OPTC ENSG00000224963 ENSG00000224963
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
LRRC23leucine rich repeat containing 23 (343 aa)
DCNdecorin; May affect the rate of fibrils formation (359 aa)
CHADLchondroadherin-like (762 aa)
UNC5CLunc-5 homolog C (C. elegans)-like; Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets (518 aa)
NEO1neogenin 1; May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues (1461 aa)
CDONCdon homolog (mouse); Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity) (1264 aa)
LRRC46leucine rich repeat containing 46 (321 aa)
NTN3netrin 3; Netrins control guidance of CNS commissural axons and peripheral motor axons (By similarity) (580 aa)
DRAXINdorsal inhibitory axon guidance protein; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway (By similarity) (349 aa)
FNDC1fibronectin type III domain containing 1 (1894 aa)
LRRK2leucine-rich repeat kinase 2; May play a role in the phosphorylation of proteins central to Parkinson disease. Phosphorylates PRDX3. May also have GTPase activity. Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (2527 aa)
GP9glycoprotein IX (platelet); The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib (177 aa)
PODNpodocan; Negatively regulates cell proliferation and cell migration (661 aa)
IGDCC4immunoglobulin superfamily, DCC subclass, member 4 (1250 aa)
UNC5Aunc-5 homolog A (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (842 aa)
IGDCC3immunoglobulin superfamily, DCC subclass, member 3 (814 aa)
UNC5Bunc-5 homolog B (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (945 aa)
LRRIQ4leucine-rich repeats and IQ motif containing 4 (560 aa)
OPTCopticin; Binds collagen fibrils (By similarity) (332 aa)
LRRC40leucine rich repeat containing 40 (602 aa)
LRRN4leucine rich repeat neuronal 4; May play an important role in hippocampus-dependent long-lasting memory (By similarity) (740 aa)
PRTGprotogenin; May play a role in anteroposterior axis elongation (By similarity) (1150 aa)
UNC5Dunc-5 homolog D (C. elegans); Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity) (953 aa)
DCCdeleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene (1447 aa)
ENSG00000224963Uncharacterized protein (125 aa)
UNC5Cunc-5 homolog C (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity) (931 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (29%)