| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BAG3 | UBC | ENSP00000358081 | ENSP00000344818 | BCL2-associated athanogene 3; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity | ubiquitin C | 0.972 |
| CD247 | UBC | ENSP00000354782 | ENSP00000344818 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | ubiquitin C | 0.897 |
| DISP1 | LAPTM5 | ENSP00000284476 | ENSP00000294507 | dispatched homolog 1 (Drosophila); Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity) | lysosomal protein transmembrane 5; May have a special functional role during embryogenesis and in adult hematopoietic cells | 0.612 |
| GGA3 | ITCH | ENSP00000245541 | ENSP00000363998 | golgi-associated, gamma adaptin ear containing, ARF binding protein 3; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif | itchy E3 ubiquitin protein ligase | 0.643 |
| GGA3 | LAPTM5 | ENSP00000245541 | ENSP00000294507 | golgi-associated, gamma adaptin ear containing, ARF binding protein 3; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif | lysosomal protein transmembrane 5; May have a special functional role during embryogenesis and in adult hematopoietic cells | 0.583 |
| GGA3 | NEDD4 | ENSP00000245541 | ENSP00000345530 | golgi-associated, gamma adaptin ear containing, ARF binding protein 3; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.715 |
| GGA3 | UBC | ENSP00000245541 | ENSP00000344818 | golgi-associated, gamma adaptin ear containing, ARF binding protein 3; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif | ubiquitin C | 0.999 |
| ITCH | GGA3 | ENSP00000363998 | ENSP00000245541 | itchy E3 ubiquitin protein ligase | golgi-associated, gamma adaptin ear containing, ARF binding protein 3; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif | 0.643 |
| ITCH | LAPTM5 | ENSP00000363998 | ENSP00000294507 | itchy E3 ubiquitin protein ligase | lysosomal protein transmembrane 5; May have a special functional role during embryogenesis and in adult hematopoietic cells | 0.603 |
| ITCH | TNFAIP3 | ENSP00000363998 | ENSP00000237289 | itchy E3 ubiquitin protein ligase | tumor necrosis factor, alpha-induced protein 3; Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes i [...] | 0.903 |
| ITCH | UBC | ENSP00000363998 | ENSP00000344818 | itchy E3 ubiquitin protein ligase | ubiquitin C | 0.999 |
| LAMP1 | LAPTM5 | ENSP00000333298 | ENSP00000294507 | lysosomal-associated membrane protein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis | lysosomal protein transmembrane 5; May have a special functional role during embryogenesis and in adult hematopoietic cells | 0.834 |
| LAMP1 | TNFAIP3 | ENSP00000333298 | ENSP00000237289 | lysosomal-associated membrane protein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis | tumor necrosis factor, alpha-induced protein 3; Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes i [...] | 0.585 |
| LAMP1 | UBC | ENSP00000333298 | ENSP00000344818 | lysosomal-associated membrane protein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis | ubiquitin C | 0.644 |
| LAPTM5 | DISP1 | ENSP00000294507 | ENSP00000284476 | lysosomal protein transmembrane 5; May have a special functional role during embryogenesis and in adult hematopoietic cells | dispatched homolog 1 (Drosophila); Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity) | 0.612 |
| LAPTM5 | GGA3 | ENSP00000294507 | ENSP00000245541 | lysosomal protein transmembrane 5; May have a special functional role during embryogenesis and in adult hematopoietic cells | golgi-associated, gamma adaptin ear containing, ARF binding protein 3; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif | 0.583 |
| LAPTM5 | ITCH | ENSP00000294507 | ENSP00000363998 | lysosomal protein transmembrane 5; May have a special functional role during embryogenesis and in adult hematopoietic cells | itchy E3 ubiquitin protein ligase | 0.603 |
| LAPTM5 | LAMP1 | ENSP00000294507 | ENSP00000333298 | lysosomal protein transmembrane 5; May have a special functional role during embryogenesis and in adult hematopoietic cells | lysosomal-associated membrane protein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis | 0.834 |
| LAPTM5 | LDLRAD1 | ENSP00000294507 | ENSP00000360411 | lysosomal protein transmembrane 5; May have a special functional role during embryogenesis and in adult hematopoietic cells | low density lipoprotein receptor class A domain containing 1 | 0.537 |
| LAPTM5 | NEDD4 | ENSP00000294507 | ENSP00000345530 | lysosomal protein transmembrane 5; May have a special functional role during embryogenesis and in adult hematopoietic cells | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.845 |
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