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TIAM1 TIAM1 FGD2 FGD2 VAV2 VAV2 SOS1 SOS1 ITSN1 ITSN1 FGD4 FGD4 VAV1 VAV1 TRIO TRIO ECT2 ECT2 ARHGDIB ARHGDIB ARHGDIA ARHGDIA ABR ABR KALRN KALRN AKAP13 AKAP13 MCF2 MCF2 ARHGAP15 ARHGAP15 TIAM2 TIAM2 ARHGEF12 ARHGEF12 RASGRF2 RASGRF2 ARHGEF2 ARHGEF2 MCF2L MCF2L ARHGEF7 ARHGEF7 ARHGEF6 ARHGEF6 PLEKHG5 PLEKHG5 NGEF NGEF
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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experimentally determined
Predicted Interactions
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textmining
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ARHGDIBRho GDP dissociation inhibitor (GDI) beta; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (201 aa)
ECT2epithelial cell transforming sequence 2 oncogene; Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to t [...] (883 aa)
KALRNkalirin, RhoGEF kinase; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity (1663 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF) (776 aa)
NGEFneuronal guanine nucleotide exchange factor; Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity) (710 aa)
RASGRF2Ras protein-specific guanine nucleotide-releasing factor 2; Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation (1237 aa)
ARHGDIARho GDP dissociation inhibitor (GDI) alpha; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity) (204 aa)
FGD2FYVE, RhoGEF and PH domain containing 2; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5- bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4- monophosphate and phosphatidylinositol 3-monophosphate (By similarity) (655 aa)
TIAM1T-cell lymphoma invasion and metastasis 1; Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA (1591 aa)
ARHGAP15Rho GTPase activating protein 15 (475 aa)
ABRactive BCR-related (859 aa)
TIAM2T-cell lymphoma invasion and metastasis 2; Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by [...] (1701 aa)
TRIOtrio Rho guanine nucleotide exchange factor; Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth (3097 aa)
AKAP13A kinase (PRKA) anchor protein 13 (2817 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor (GEF) 2; Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed-9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras- GTPases. Forms an intracellular sensing sys [...] (986 aa)
VAV2vav 2 guanine nucleotide exchange factor (878 aa)
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 7 (803 aa)
PLEKHG5pleckstrin homology domain containing, family G (with RhoGef domain) member 5 (1083 aa)
ITSN1intersectin 1 (SH3 domain protein); Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1 (1721 aa)
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 12; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 (1544 aa)
SOS1son of sevenless homolog 1 (Drosophila); Promotes the exchange of Ras-bound GDP by GTP. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity) (1333 aa)
FGD4FYVE, RhoGEF and PH domain containing 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity) (766 aa)
MCF2MCF.2 cell line derived transforming sequence (1001 aa)
MCF2LMCF.2 cell line derived transforming sequence-like (1125 aa)
VAV1vav 1 guanine nucleotide exchange factor; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation (845 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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