Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | SRP54 | signal recognition particle 54kDa; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein) (504 aa) | ||
 | MRPL32 | mitochondrial ribosomal protein L32 (188 aa) | ||
 | PNPO | pyridoxamine 5’-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5’- phosphate (PNP) or pyridoxamine 5’-phosphate (PMP) into pyridoxal 5’-phosphate (PLP) (261 aa) | ||
 | MRPL27 | mitochondrial ribosomal protein L27 (148 aa) | ||
 | MRPL34 | mitochondrial ribosomal protein L34 (92 aa) | ||
 | RPL35 | ribosomal protein L35 (123 aa) | ||
 | RPL8 | ribosomal protein L8 (257 aa) | ||
 | PTS | 6-pyruvoyltetrahydropterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin (145 aa) | ||
 | MRPL17 | mitochondrial ribosomal protein L17 (175 aa) | ||
 | PDXK | pyridoxal (pyridoxine, vitamin B6) kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6 (312 aa) | ||
 | ALPI | alkaline phosphatase, intestinal (528 aa) | ||
 | MRPL33 | mitochondrial ribosomal protein L33 (65 aa) | ||
 | MRPL11 | mitochondrial ribosomal protein L11 (192 aa) | ||
 | SRPR | signal recognition particle receptor (docking protein); Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (638 aa) | ||
 | RPLP0 | ribosomal protein, large, P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10 (By similarity) (317 aa) | ||
 | RPL27A | ribosomal protein L27a (148 aa) | ||
 | RPL9 | ribosomal protein L9 (192 aa) | ||
 | RPL12 | ribosomal protein L12; Binds directly to 26S ribosomal RNA (By similarity) (165 aa) | ||
 | RPL5 | ribosomal protein L5; Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA (297 aa) | ||
 | RPL11 | ribosomal protein L11; Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML (By similarity) (178 aa) | ||
 | MRTO4 | mRNA turnover 4 homolog (S. cerevisiae); Involved in mRNA turnover and ribosome assembly (By similarity) (239 aa) | ||
 | MRPL36 | mitochondrial ribosomal protein L36; Component of the large subunit of the mitochondrial ribosome (Potential) (103 aa) | ||
 | MRPL19 | mitochondrial ribosomal protein L19 (292 aa) | ||
 | RPL23 | ribosomal protein L23 (140 aa) | ||
 | GCH1 | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown (250 aa) | ||
 | RPL23A | ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA (By similarity) (156 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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