node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD289 | STK11IP | ENSP00000417517 | ENSP00000295641 | TLR9 | serine/threonine kinase 11 interacting protein; May regulate STK11/LKB1 function by controlling its subcellular localization | 0.459 |
SMAD4 | STK11 | ENSP00000341551 | ENSP00000324856 | SMAD family member 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. [...] | serine/threonine kinase 11; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity- phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA and possibly p53/TP53. Acts as a [...] | 0.987 |
SMAD4 | STK11IP | ENSP00000341551 | ENSP00000295641 | SMAD family member 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. [...] | serine/threonine kinase 11 interacting protein; May regulate STK11/LKB1 function by controlling its subcellular localization | 0.995 |
SMAD4 | UBC | ENSP00000341551 | ENSP00000344818 | SMAD family member 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. [...] | ubiquitin C | 0.999 |
STK11 | SMAD4 | ENSP00000324856 | ENSP00000341551 | serine/threonine kinase 11; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity- phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA and possibly p53/TP53. Acts as a [...] | SMAD family member 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. [...] | 0.987 |
STK11 | STK11IP | ENSP00000324856 | ENSP00000295641 | serine/threonine kinase 11; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity- phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA and possibly p53/TP53. Acts as a [...] | serine/threonine kinase 11 interacting protein; May regulate STK11/LKB1 function by controlling its subcellular localization | 0.995 |
STK11 | UBC | ENSP00000324856 | ENSP00000344818 | serine/threonine kinase 11; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity- phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA and possibly p53/TP53. Acts as a [...] | ubiquitin C | 0.626 |
STK11IP | CD289 | ENSP00000295641 | ENSP00000417517 | serine/threonine kinase 11 interacting protein; May regulate STK11/LKB1 function by controlling its subcellular localization | TLR9 | 0.459 |
STK11IP | SMAD4 | ENSP00000295641 | ENSP00000341551 | serine/threonine kinase 11 interacting protein; May regulate STK11/LKB1 function by controlling its subcellular localization | SMAD family member 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. [...] | 0.995 |
STK11IP | STK11 | ENSP00000295641 | ENSP00000324856 | serine/threonine kinase 11 interacting protein; May regulate STK11/LKB1 function by controlling its subcellular localization | serine/threonine kinase 11; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity- phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA and possibly p53/TP53. Acts as a [...] | 0.995 |
STK11IP | TLR4 | ENSP00000295641 | ENSP00000363089 | serine/threonine kinase 11 interacting protein; May regulate STK11/LKB1 function by controlling its subcellular localization | toll-like receptor 4 | 0.456 |
STK11IP | TLR9 | ENSP00000295641 | ENSP00000353874 | serine/threonine kinase 11 interacting protein; May regulate STK11/LKB1 function by controlling its subcellular localization | toll-like receptor 9 | 0.447 |
STK11IP | UBC | ENSP00000295641 | ENSP00000344818 | serine/threonine kinase 11 interacting protein; May regulate STK11/LKB1 function by controlling its subcellular localization | ubiquitin C | 0.623 |
TLR4 | STK11IP | ENSP00000363089 | ENSP00000295641 | toll-like receptor 4 | serine/threonine kinase 11 interacting protein; May regulate STK11/LKB1 function by controlling its subcellular localization | 0.456 |
TLR4 | UBC | ENSP00000363089 | ENSP00000344818 | toll-like receptor 4 | ubiquitin C | 0.851 |
TLR9 | STK11IP | ENSP00000353874 | ENSP00000295641 | toll-like receptor 9 | serine/threonine kinase 11 interacting protein; May regulate STK11/LKB1 function by controlling its subcellular localization | 0.447 |
UBC | SMAD4 | ENSP00000344818 | ENSP00000341551 | ubiquitin C | SMAD family member 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. [...] | 0.999 |
UBC | STK11 | ENSP00000344818 | ENSP00000324856 | ubiquitin C | serine/threonine kinase 11; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity- phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA and possibly p53/TP53. Acts as a [...] | 0.626 |
UBC | STK11IP | ENSP00000344818 | ENSP00000295641 | ubiquitin C | serine/threonine kinase 11 interacting protein; May regulate STK11/LKB1 function by controlling its subcellular localization | 0.623 |
UBC | TLR4 | ENSP00000344818 | ENSP00000363089 | ubiquitin C | toll-like receptor 4 | 0.851 |