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STRINGSTRING
CLEC7A CLEC7A RPRM RPRM TMEM100 TMEM100 TMPRSS4 TMPRSS4 TNMD TNMD TMEM79 TMEM79 SERP1 SERP1 TEX264 TEX264 SEC22A SEC22A SFTPC SFTPC PLN PLN RNF8 RNF8 SLN SLN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
SERP1stress-associated endoplasmic reticulum protein 1; Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By similarity) (66 aa)
TMEM79transmembrane protein 79 (394 aa)
CLEC7AC-type lectin domain family 7, member A (247 aa)
SLNsarcolipin (31 aa)
SEC22ASEC22 vesicle trafficking protein homolog A (S. cerevisiae); May be involved in vesicle transport between the ER and the Golgi complex (By similarity) (307 aa)
RPRMreprimo, TP53 dependent G2 arrest mediator candidate; May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity) (109 aa)
SFTPCsurfactant protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces (197 aa)
TEX264testis expressed 264 (313 aa)
PLNphospholamban; Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum (52 aa)
TNMDtenomodulin; May be an angiogenesis inhibitor (317 aa)
RNF8ring finger protein 8, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles- by mediating the ’Lys-63’- linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing ’Lys-48’-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the ’Lys-63’-linked ubiquitination of histones H2A and H2AX, thereby promoting th [...] (485 aa)
TMEM100transmembrane protein 100 (134 aa)
TMPRSS4transmembrane protease, serine 4; Probable protease. Seems to be capable of activating ENaC (By similarity) (437 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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