node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EGFR | FLT1 | ENSP00000275493 | ENSP00000282397 | epidermal growth factor receptor | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | 0.539 |
EGFR | KIAA1524 | ENSP00000275493 | ENSP00000295746 | epidermal growth factor receptor | KIAA1524; Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation | 0.435 |
EGFR | MYC | ENSP00000275493 | ENSP00000367207 | epidermal growth factor receptor | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | 0.960 |
EGFR | PPP2R1A | ENSP00000275493 | ENSP00000324804 | epidermal growth factor receptor | protein phosphatase 2, regulatory subunit A, alpha; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis | 0.928 |
EGFR | STUB1 | ENSP00000275493 | ENSP00000219548 | epidermal growth factor receptor | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates- ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 th [...] | 0.856 |
EGFR | UBC | ENSP00000275493 | ENSP00000344818 | epidermal growth factor receptor | ubiquitin C | 0.999 |
FLT1 | EGFR | ENSP00000282397 | ENSP00000275493 | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | epidermal growth factor receptor | 0.539 |
FLT1 | KIAA1524 | ENSP00000282397 | ENSP00000295746 | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | KIAA1524; Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation | 0.570 |
FLT1 | MYC | ENSP00000282397 | ENSP00000367207 | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | 0.416 |
FLT1 | UBC | ENSP00000282397 | ENSP00000344818 | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | ubiquitin C | 0.650 |
IK | KIAA1524 | ENSP00000396301 | ENSP00000295746 | IK cytokine, down-regulator of HLA II; May bind to chromatin | KIAA1524; Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation | 0.576 |
IK | UBC | ENSP00000396301 | ENSP00000344818 | IK cytokine, down-regulator of HLA II; May bind to chromatin | ubiquitin C | 0.889 |
KIAA1524 | EGFR | ENSP00000295746 | ENSP00000275493 | KIAA1524; Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation | epidermal growth factor receptor | 0.435 |
KIAA1524 | FLT1 | ENSP00000295746 | ENSP00000282397 | KIAA1524; Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | 0.570 |
KIAA1524 | IK | ENSP00000295746 | ENSP00000396301 | KIAA1524; Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation | IK cytokine, down-regulator of HLA II; May bind to chromatin | 0.576 |
KIAA1524 | MYC | ENSP00000295746 | ENSP00000367207 | KIAA1524; Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | 0.979 |
KIAA1524 | PPP2R1A | ENSP00000295746 | ENSP00000324804 | KIAA1524; Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation | protein phosphatase 2, regulatory subunit A, alpha; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis | 0.851 |
KIAA1524 | STUB1 | ENSP00000295746 | ENSP00000219548 | KIAA1524; Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates- ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 th [...] | 0.581 |
KIAA1524 | UBC | ENSP00000295746 | ENSP00000344818 | KIAA1524; Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation | ubiquitin C | 0.945 |
MYC | EGFR | ENSP00000367207 | ENSP00000275493 | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | epidermal growth factor receptor | 0.960 |