Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | GRN | granulin (593 aa) | ||
 | GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis (247 aa) | ||
 | PLAT | plasminogen activator, tissue (562 aa) | ||
 | PRSS36 | protease, serine, 36; Serine protease. Hydrolyzes the peptides N-t-Boc-Gln- Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC and, to a lesser extent, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Val-Leu-Lys-AMC. Has a preference for substrates with an Arg instead of a Lys residue in position P1 (855 aa) | ||
 | PAMR1 | peptidase domain containing associated with muscle regeneration 1; May play a role in regeneration of skeletal muscle (By similarity) (737 aa) | ||
 | TMPRSS11D | transmembrane protease, serine 11D; May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions (418 aa) | ||
 | TMPRSS15 | transmembrane protease, serine 15; Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases (1019 aa) | ||
 | TMPRSS3 | transmembrane protease, serine 3; Probable serine protease that play a role in hearing. Acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro) (454 aa) | ||
 | PRSS33 | protease, serine, 33; Serine protease that has amidolytic activity, cleaving its substrates before Arg residues (280 aa) | ||
 | SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1; Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (410 aa) | ||
 | TMPRSS5 | transmembrane protease, serine 5; May play a role in hearing (457 aa) | ||
 | CTRB2 | chymotrypsinogen B2 (263 aa) | ||
 | PLG | plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (810 aa) | ||
 | KLK2 | kallikrein-related peptidase 2; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin (261 aa) | ||
 | OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin (667 aa) | ||
 | LPA | lipoprotein, Lp(a); Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330 (2040 aa) | ||
 | CELA3B | chymotrypsin-like elastase family, member 3B; Efficient protease with alanine specificity but only little elastolytic activity (270 aa) | ||
 | MAX | MYC associated factor X; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5’-CAC[GA]TG-3’. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 ’Lys-9’ histone methyltransferase activity (160 aa) | ||
 | PRSS3 | protease, serine, 3; Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5 (304 aa) | ||
 | KLK9 | kallikrein-related peptidase 9 (250 aa) | ||
 | MYC | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes (454 aa) | ||
 | PRSS42 | protease, serine, 42 (293 aa) | ||
 | TMPRSS7 | transmembrane protease, serine 7; Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position (By similarity) (717 aa) | ||
 | TMPRSS4 | transmembrane protease, serine 4; Probable protease. Seems to be capable of activating ENaC (By similarity) (437 aa) | ||
 | PRSS46 | protease, serine, 46 (174 aa) | ||
 | KLK13 | kallikrein-related peptidase 13 (277 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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