node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAPZB | UBC | ENSP00000264202 | ENSP00000344818 | capping protein (actin filament) muscle Z-line, beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization | ubiquitin C | 0.897 |
ELAVL1 | NOVA1 | ENSP00000385269 | ENSP00000438875 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | neuro-oncological ventral antigen 1; May regulate RNA splicing or metabolism in a specific subset of developing neurons | 0.434 |
ELAVL1 | UBC | ENSP00000385269 | ENSP00000344818 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | ubiquitin C | 0.998 |
ENSG00000255154 | POP4 | ENSP00000437142 | ENSP00000465213 | Hydroxyacyl-thioester dehydratase type 2, mitochondrial ; Mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis | processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae); Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P | 0.999 |
ENSG00000255154 | POP5 | ENSP00000437142 | ENSP00000350098 | Hydroxyacyl-thioester dehydratase type 2, mitochondrial ; Mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis | processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae); Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. Also a component of RNase MRP | 0.999 |
ENSG00000255154 | RPP14 | ENSP00000437142 | ENSP00000295959 | Hydroxyacyl-thioester dehydratase type 2, mitochondrial ; Mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis | ribonuclease P/MRP 14kDa subunit; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends | 0.999 |
ENSG00000255154 | RPP25 | ENSP00000437142 | ENSP00000317691 | Hydroxyacyl-thioester dehydratase type 2, mitochondrial ; Mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis | ribonuclease P/MRP 25kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. Also a component of RNase MRP. This subunit binds to RNA | 0.999 |
ENSG00000255154 | RPP30 | ENSP00000437142 | ENSP00000389182 | Hydroxyacyl-thioester dehydratase type 2, mitochondrial ; Mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis | ribonuclease P/MRP 30kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends | 0.595 |
ENSG00000255154 | RPP40 | ENSP00000437142 | ENSP00000369391 | Hydroxyacyl-thioester dehydratase type 2, mitochondrial ; Mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis | ribonuclease P/MRP 40kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends | 0.999 |
NOVA1 | ELAVL1 | ENSP00000438875 | ENSP00000385269 | neuro-oncological ventral antigen 1; May regulate RNA splicing or metabolism in a specific subset of developing neurons | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | 0.434 |
POP4 | ENSG00000255154 | ENSP00000465213 | ENSP00000437142 | processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae); Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P | Hydroxyacyl-thioester dehydratase type 2, mitochondrial ; Mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis | 0.999 |
POP4 | POP5 | ENSP00000465213 | ENSP00000350098 | processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae); Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P | processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae); Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. Also a component of RNase MRP | 0.999 |
POP4 | RPP14 | ENSP00000465213 | ENSP00000295959 | processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae); Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P | ribonuclease P/MRP 14kDa subunit; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends | 0.999 |
POP4 | RPP25 | ENSP00000465213 | ENSP00000317691 | processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae); Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P | ribonuclease P/MRP 25kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. Also a component of RNase MRP. This subunit binds to RNA | 0.999 |
POP4 | RPP30 | ENSP00000465213 | ENSP00000389182 | processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae); Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P | ribonuclease P/MRP 30kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends | 0.998 |
POP4 | RPP40 | ENSP00000465213 | ENSP00000369391 | processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae); Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P | ribonuclease P/MRP 40kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends | 0.881 |
POP4 | UBC | ENSP00000465213 | ENSP00000344818 | processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae); Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P | ubiquitin C | 0.638 |
POP5 | ENSG00000255154 | ENSP00000350098 | ENSP00000437142 | processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae); Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. Also a component of RNase MRP | Hydroxyacyl-thioester dehydratase type 2, mitochondrial ; Mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis | 0.999 |
POP5 | POP4 | ENSP00000350098 | ENSP00000465213 | processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae); Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. Also a component of RNase MRP | processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae); Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P | 0.999 |
POP5 | RPP14 | ENSP00000350098 | ENSP00000295959 | processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae); Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. Also a component of RNase MRP | ribonuclease P/MRP 14kDa subunit; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends | 0.999 |