node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IL17A | IL17RA | ENSP00000344192 | ENSP00000320936 | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | interleukin 17 receptor A; Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling | 0.999 |
IL17A | IL17RC | ENSP00000344192 | ENSP00000295981 | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | interleukin 17 receptor C | 0.953 |
IL17A | IL25 | ENSP00000344192 | ENSP00000328111 | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | interleukin 25; Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses | 0.720 |
IL17A | TRAF3IP2 | ENSP00000344192 | ENSP00000357750 | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | TRAF3 interacting protein 2 | 0.960 |
IL17F | IL17RA | ENSP00000337432 | ENSP00000320936 | interleukin 17F; Stimulates the production of other cytokines such as IL- 6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis | interleukin 17 receptor A; Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling | 0.993 |
IL17F | IL17RC | ENSP00000337432 | ENSP00000295981 | interleukin 17F; Stimulates the production of other cytokines such as IL- 6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis | interleukin 17 receptor C | 0.724 |
IL17F | IL25 | ENSP00000337432 | ENSP00000328111 | interleukin 17F; Stimulates the production of other cytokines such as IL- 6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis | interleukin 25; Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses | 0.624 |
IL17F | TRAF3IP2 | ENSP00000337432 | ENSP00000357750 | interleukin 17F; Stimulates the production of other cytokines such as IL- 6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis | TRAF3 interacting protein 2 | 0.452 |
IL17RA | IL17A | ENSP00000320936 | ENSP00000344192 | interleukin 17 receptor A; Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | 0.999 |
IL17RA | IL17F | ENSP00000320936 | ENSP00000337432 | interleukin 17 receptor A; Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling | interleukin 17F; Stimulates the production of other cytokines such as IL- 6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis | 0.993 |
IL17RA | IL17RC | ENSP00000320936 | ENSP00000295981 | interleukin 17 receptor A; Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling | interleukin 17 receptor C | 0.470 |
IL17RA | IL25 | ENSP00000320936 | ENSP00000328111 | interleukin 17 receptor A; Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling | interleukin 25; Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses | 0.740 |
IL17RA | TRAF3IP2 | ENSP00000320936 | ENSP00000357750 | interleukin 17 receptor A; Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling | TRAF3 interacting protein 2 | 0.983 |
IL17RC | IL17A | ENSP00000295981 | ENSP00000344192 | interleukin 17 receptor C | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | 0.953 |
IL17RC | IL17F | ENSP00000295981 | ENSP00000337432 | interleukin 17 receptor C | interleukin 17F; Stimulates the production of other cytokines such as IL- 6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis | 0.724 |
IL17RC | IL17RA | ENSP00000295981 | ENSP00000320936 | interleukin 17 receptor C | interleukin 17 receptor A; Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling | 0.470 |
IL17RC | IL25 | ENSP00000295981 | ENSP00000328111 | interleukin 17 receptor C | interleukin 25; Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses | 0.711 |
IL17RC | TRAF3IP2 | ENSP00000295981 | ENSP00000357750 | interleukin 17 receptor C | TRAF3 interacting protein 2 | 0.595 |
IL25 | IL17A | ENSP00000328111 | ENSP00000344192 | interleukin 25; Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | 0.720 |
IL25 | IL17F | ENSP00000328111 | ENSP00000337432 | interleukin 25; Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses | interleukin 17F; Stimulates the production of other cytokines such as IL- 6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis | 0.624 |