node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGT | ATP6AP2 | ENSP00000355627 | ENSP00000367697 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | ATPase, H+ transporting, lysosomal accessory protein 2 | 0.981 |
AGT | CPA3 | ENSP00000355627 | ENSP00000296046 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | carboxypeptidase A3 (mast cell) | 0.904 |
AGT | CTSD | ENSP00000355627 | ENSP00000236671 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | cathepsin D; Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease | 0.653 |
AGT | REN | ENSP00000355627 | ENSP00000272190 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney | 0.999 |
ATP6AP2 | AGT | ENSP00000367697 | ENSP00000355627 | ATPase, H+ transporting, lysosomal accessory protein 2 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | 0.981 |
ATP6AP2 | CPA3 | ENSP00000367697 | ENSP00000296046 | ATPase, H+ transporting, lysosomal accessory protein 2 | carboxypeptidase A3 (mast cell) | 0.900 |
ATP6AP2 | REN | ENSP00000367697 | ENSP00000272190 | ATPase, H+ transporting, lysosomal accessory protein 2 | renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney | 0.985 |
CELA2A | CELA3A | ENSP00000352639 | ENSP00000290122 | chymotrypsin-like elastase family, member 2A; Acts upon elastin | chymotrypsin-like elastase family, member 3A; Efficient protease with alanine specificity but only little elastolytic activity | 0.531 |
CELA2A | CELA3B | ENSP00000352639 | ENSP00000338369 | chymotrypsin-like elastase family, member 2A; Acts upon elastin | chymotrypsin-like elastase family, member 3B; Efficient protease with alanine specificity but only little elastolytic activity | 0.530 |
CELA2B | CELA3A | ENSP00000365075 | ENSP00000290122 | chymotrypsin-like elastase family, member 2B; Acts upon elastin | chymotrypsin-like elastase family, member 3A; Efficient protease with alanine specificity but only little elastolytic activity | 0.530 |
CELA2B | CELA3B | ENSP00000365075 | ENSP00000338369 | chymotrypsin-like elastase family, member 2B; Acts upon elastin | chymotrypsin-like elastase family, member 3B; Efficient protease with alanine specificity but only little elastolytic activity | 0.525 |
CELA3A | CELA2A | ENSP00000290122 | ENSP00000352639 | chymotrypsin-like elastase family, member 3A; Efficient protease with alanine specificity but only little elastolytic activity | chymotrypsin-like elastase family, member 2A; Acts upon elastin | 0.531 |
CELA3A | CELA2B | ENSP00000290122 | ENSP00000365075 | chymotrypsin-like elastase family, member 3A; Efficient protease with alanine specificity but only little elastolytic activity | chymotrypsin-like elastase family, member 2B; Acts upon elastin | 0.530 |
CELA3A | CTRC | ENSP00000290122 | ENSP00000365116 | chymotrypsin-like elastase family, member 3A; Efficient protease with alanine specificity but only little elastolytic activity | chymotrypsin C (caldecrin); Has chymotrypsin-type protease activity and hypocalcemic activity | 0.469 |
CELA3B | CELA2A | ENSP00000338369 | ENSP00000352639 | chymotrypsin-like elastase family, member 3B; Efficient protease with alanine specificity but only little elastolytic activity | chymotrypsin-like elastase family, member 2A; Acts upon elastin | 0.530 |
CELA3B | CELA2B | ENSP00000338369 | ENSP00000365075 | chymotrypsin-like elastase family, member 3B; Efficient protease with alanine specificity but only little elastolytic activity | chymotrypsin-like elastase family, member 2B; Acts upon elastin | 0.525 |
CELA3B | CTRC | ENSP00000338369 | ENSP00000365116 | chymotrypsin-like elastase family, member 3B; Efficient protease with alanine specificity but only little elastolytic activity | chymotrypsin C (caldecrin); Has chymotrypsin-type protease activity and hypocalcemic activity | 0.463 |
CPA3 | AGT | ENSP00000296046 | ENSP00000355627 | carboxypeptidase A3 (mast cell) | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | 0.904 |
CPA3 | ATP6AP2 | ENSP00000296046 | ENSP00000367697 | carboxypeptidase A3 (mast cell) | ATPase, H+ transporting, lysosomal accessory protein 2 | 0.900 |
CPA3 | REN | ENSP00000296046 | ENSP00000272190 | carboxypeptidase A3 (mast cell) | renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney | 0.904 |