Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
CPA3 CPA3 PGA4 PGA4 ATP6AP2 ATP6AP2 REN REN PCSK6 PCSK6 AGT AGT PCSK7 PCSK7 PGA3 PGA3 PCSK5 PCSK5 CTSD CTSD PGA5 PGA5 CELA2A CELA2A LBR LBR CELA3B CELA3B CTRC CTRC CELA3A CELA3A CELA2B CELA2B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
CTSDcathepsin D; Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease (412 aa)
LBRlamin B receptor; Anchors the lamina and the heterochromatin to the inner nuclear membrane (615 aa)
RENrenin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney (406 aa)
CELA3Achymotrypsin-like elastase family, member 3A; Efficient protease with alanine specificity but only little elastolytic activity (270 aa)
CPA3carboxypeptidase A3 (mast cell) (417 aa)
PCSK6proprotein convertase subtilisin/kexin type 6 (968 aa)
PGA5pepsinogen 5, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (388 aa)
PGA3pepsinogen 3, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (388 aa)
PCSK7proprotein convertase subtilisin/kexin type 7; Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif (785 aa)
CELA3Bchymotrypsin-like elastase family, member 3B; Efficient protease with alanine specificity but only little elastolytic activity (270 aa)
CELA2Achymotrypsin-like elastase family, member 2A; Acts upon elastin (269 aa)
AGTangiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis (485 aa)
CELA2Bchymotrypsin-like elastase family, member 2B; Acts upon elastin (269 aa)
CTRCchymotrypsin C (caldecrin); Has chymotrypsin-type protease activity and hypocalcemic activity (268 aa)
PGA4pepsinogen 4, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (388 aa)
ATP6AP2ATPase, H+ transporting, lysosomal accessory protein 2 (350 aa)
PCSK5proprotein convertase subtilisin/kexin type 5; Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins (1860 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (37%)