node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BECN1 | EGFR | ENSP00000355231 | ENSP00000275493 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | epidermal growth factor receptor | 0.725 |
BECN1 | EXOC2 | ENSP00000355231 | ENSP00000230449 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | 0.618 |
BECN1 | KIAA0226 | ENSP00000355231 | ENSP00000296343 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | KIAA0226; Negatively regulates endocytic trafficking. Impairs the autophagosome maturation process. May inhibit PIK3C3 activity (By similarity) | 0.999 |
BECN1 | PIK3C3 | ENSP00000355231 | ENSP00000262039 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | phosphatidylinositol 3-kinase, catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes | 0.999 |
BECN1 | PIK3R4 | ENSP00000355231 | ENSP00000349205 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | phosphoinositide-3-kinase, regulatory subunit 4; Regulatory subunit of the PI3K complex. May regulate membrane trafficking late in the endocytic pathway | 0.999 |
BECN1 | PRDM10 | ENSP00000355231 | ENSP00000351686 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | PR domain containing 10 | 0.404 |
BECN1 | UVRAG | ENSP00000355231 | ENSP00000348455 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | UV radiation resistance associated | 0.999 |
EGFR | BECN1 | ENSP00000275493 | ENSP00000355231 | epidermal growth factor receptor | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | 0.725 |
EGFR | KIAA0226 | ENSP00000275493 | ENSP00000296343 | epidermal growth factor receptor | KIAA0226; Negatively regulates endocytic trafficking. Impairs the autophagosome maturation process. May inhibit PIK3C3 activity (By similarity) | 0.609 |
EGFR | PRDM10 | ENSP00000275493 | ENSP00000351686 | epidermal growth factor receptor | PR domain containing 10 | 0.730 |
EXOC1 | EXOC2 | ENSP00000326514 | ENSP00000230449 | exocyst complex component 1; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | 0.999 |
EXOC1 | EXOC8 | ENSP00000326514 | ENSP00000353564 | exocyst complex component 1; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | exocyst complex component 8; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | 0.999 |
EXOC2 | BECN1 | ENSP00000230449 | ENSP00000355231 | exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | 0.618 |
EXOC2 | EXOC1 | ENSP00000230449 | ENSP00000326514 | exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | exocyst complex component 1; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | 0.999 |
EXOC2 | EXOC8 | ENSP00000230449 | ENSP00000353564 | exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | exocyst complex component 8; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | 0.999 |
EXOC8 | EXOC1 | ENSP00000353564 | ENSP00000326514 | exocyst complex component 8; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | exocyst complex component 1; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | 0.999 |
EXOC8 | EXOC2 | ENSP00000353564 | ENSP00000230449 | exocyst complex component 8; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane | 0.999 |
KIAA0226 | BECN1 | ENSP00000296343 | ENSP00000355231 | KIAA0226; Negatively regulates endocytic trafficking. Impairs the autophagosome maturation process. May inhibit PIK3C3 activity (By similarity) | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | 0.999 |
KIAA0226 | EGFR | ENSP00000296343 | ENSP00000275493 | KIAA0226; Negatively regulates endocytic trafficking. Impairs the autophagosome maturation process. May inhibit PIK3C3 activity (By similarity) | epidermal growth factor receptor | 0.609 |
KIAA0226 | PIK3C3 | ENSP00000296343 | ENSP00000262039 | KIAA0226; Negatively regulates endocytic trafficking. Impairs the autophagosome maturation process. May inhibit PIK3C3 activity (By similarity) | phosphatidylinositol 3-kinase, catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes | 0.999 |