node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BECN1 | EGFR | ENSP00000355231 | ENSP00000275493 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | epidermal growth factor receptor | 0.725 |
BECN1 | KIAA0226 | ENSP00000355231 | ENSP00000296343 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | KIAA0226; Negatively regulates endocytic trafficking. Impairs the autophagosome maturation process. May inhibit PIK3C3 activity (By similarity) | 0.999 |
BECN1 | PIK3C3 | ENSP00000355231 | ENSP00000262039 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | phosphatidylinositol 3-kinase, catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes | 0.999 |
BECN1 | PIK3R4 | ENSP00000355231 | ENSP00000349205 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | phosphoinositide-3-kinase, regulatory subunit 4; Regulatory subunit of the PI3K complex. May regulate membrane trafficking late in the endocytic pathway | 0.999 |
BECN1 | UVRAG | ENSP00000355231 | ENSP00000348455 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | UV radiation resistance associated | 0.999 |
EGFR | BECN1 | ENSP00000275493 | ENSP00000355231 | epidermal growth factor receptor | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | 0.725 |
EGFR | KIAA0226 | ENSP00000275493 | ENSP00000296343 | epidermal growth factor receptor | KIAA0226; Negatively regulates endocytic trafficking. Impairs the autophagosome maturation process. May inhibit PIK3C3 activity (By similarity) | 0.609 |
KIAA0226 | BECN1 | ENSP00000296343 | ENSP00000355231 | KIAA0226; Negatively regulates endocytic trafficking. Impairs the autophagosome maturation process. May inhibit PIK3C3 activity (By similarity) | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | 0.999 |
KIAA0226 | EGFR | ENSP00000296343 | ENSP00000275493 | KIAA0226; Negatively regulates endocytic trafficking. Impairs the autophagosome maturation process. May inhibit PIK3C3 activity (By similarity) | epidermal growth factor receptor | 0.609 |
KIAA0226 | PIK3C3 | ENSP00000296343 | ENSP00000262039 | KIAA0226; Negatively regulates endocytic trafficking. Impairs the autophagosome maturation process. May inhibit PIK3C3 activity (By similarity) | phosphatidylinositol 3-kinase, catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes | 0.999 |
KIAA0226 | PIK3R4 | ENSP00000296343 | ENSP00000349205 | KIAA0226; Negatively regulates endocytic trafficking. Impairs the autophagosome maturation process. May inhibit PIK3C3 activity (By similarity) | phosphoinositide-3-kinase, regulatory subunit 4; Regulatory subunit of the PI3K complex. May regulate membrane trafficking late in the endocytic pathway | 0.919 |
KIAA0226 | UVRAG | ENSP00000296343 | ENSP00000348455 | KIAA0226; Negatively regulates endocytic trafficking. Impairs the autophagosome maturation process. May inhibit PIK3C3 activity (By similarity) | UV radiation resistance associated | 0.993 |
NDE1 | NDEL1 | ENSP00000345892 | ENSP00000333982 | nudE nuclear distribution E homolog 1 (A. nidulans); Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative [...] | nudE nuclear distribution E homolog (A. nidulans)-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integri [...] | 0.931 |
NDEL1 | NDE1 | ENSP00000333982 | ENSP00000345892 | nudE nuclear distribution E homolog (A. nidulans)-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integri [...] | nudE nuclear distribution E homolog 1 (A. nidulans); Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative [...] | 0.931 |
PIK3C3 | BECN1 | ENSP00000262039 | ENSP00000355231 | phosphatidylinositol 3-kinase, catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | 0.999 |
PIK3C3 | KIAA0226 | ENSP00000262039 | ENSP00000296343 | phosphatidylinositol 3-kinase, catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes | KIAA0226; Negatively regulates endocytic trafficking. Impairs the autophagosome maturation process. May inhibit PIK3C3 activity (By similarity) | 0.999 |
PIK3C3 | PIK3R4 | ENSP00000262039 | ENSP00000349205 | phosphatidylinositol 3-kinase, catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes | phosphoinositide-3-kinase, regulatory subunit 4; Regulatory subunit of the PI3K complex. May regulate membrane trafficking late in the endocytic pathway | 0.999 |
PIK3C3 | UVRAG | ENSP00000262039 | ENSP00000348455 | phosphatidylinositol 3-kinase, catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes | UV radiation resistance associated | 0.995 |
PIK3R4 | BECN1 | ENSP00000349205 | ENSP00000355231 | phosphoinositide-3-kinase, regulatory subunit 4; Regulatory subunit of the PI3K complex. May regulate membrane trafficking late in the endocytic pathway | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | 0.999 |
PIK3R4 | KIAA0226 | ENSP00000349205 | ENSP00000296343 | phosphoinositide-3-kinase, regulatory subunit 4; Regulatory subunit of the PI3K complex. May regulate membrane trafficking late in the endocytic pathway | KIAA0226; Negatively regulates endocytic trafficking. Impairs the autophagosome maturation process. May inhibit PIK3C3 activity (By similarity) | 0.919 |