Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | NIP7 | nuclear import 7 homolog (S. cerevisiae); Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly (180 aa) | ||
 | HECW2 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2; E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (1572 aa) | ||
 | LARS2 | leucyl-tRNA synthetase 2, mitochondrial (903 aa) | ||
 | MKI67IP | MKI67 (FHA domain) interacting nucleolar phosphoprotein (293 aa) | ||
 | RPL30 | ribosomal protein L30 (115 aa) | ||
 | METAP1 | methionyl aminopeptidase 1; Removes the N-terminal methionine from nascent proteins. Required for normal progression through the cell cycle (386 aa) | ||
 | NMD3 | NMD3 homolog (S. cerevisiae); Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit (503 aa) | ||
 | RPTN | repetin; Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium (784 aa) | ||
 | DDX54 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 54; Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors (882 aa) | ||
 | METAP2 | methionyl aminopeptidase 2; Removes the N-terminal methionine from nascent proteins. The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo (478 aa) | ||
 | SETD3 | SET domain containing 3 (594 aa) | ||
 | SETD4 | SET domain containing 4 (440 aa) | ||
 | UBC | ubiquitin C (685 aa) | ||
 | PES1 | pescadillo ribosomal biogenesis factor 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome (588 aa) | ||
 | SDAD1 | SDA1 domain containing 1; Required for 60S pre-ribosomal subunits export to the cytoplasm (By similarity) (687 aa) | ||
 | CBWD1 | COBW domain containing 1 (395 aa) | ||
 | GTPBP4 | GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity) (634 aa) | ||
 | MDN1 | MDN1, midasin homolog (yeast); Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (By similarity) (5596 aa) | ||
 | RPL5 | ribosomal protein L5; Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA (297 aa) | ||
 | RAE1 | RAE1 RNA export 1 homolog (S. pombe); Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton (368 aa) | ||
 | EIF6 | eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity (245 aa) | ||
 | DNAJC21 | DnaJ (Hsp40) homolog, subfamily C, member 21; May act as a co-chaperone for HSP70 (576 aa) | ||
 | LARS | leucyl-tRNA synthetase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction- the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs (1176 aa) | ||
 | UBA52 | ubiquitin A-52 residue ribosomal protein fusion product 1 (128 aa) | ||
 | RPL23A | ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA (By similarity) (156 aa) | ||
 | RPF2 | ribosome production factor 2 homolog (S. cerevisiae) (306 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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