node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACOT13 | NDUFAF2 | ENSP00000230048 | ENSP00000296597 | acyl-CoA thioesterase 13; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3- hydroxyphenylacetyl-CoA and 3,4-dihydrohyphenylacetyl-CoA (in vitro) | NADH dehydrogenase (ubiquinone) complex I, assembly factor 2; Acts as a molecular chaperone for mitochondrial complex I assembly | 0.644 |
ACOT13 | UBC | ENSP00000230048 | ENSP00000344818 | acyl-CoA thioesterase 13; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3- hydroxyphenylacetyl-CoA and 3,4-dihydrohyphenylacetyl-CoA (in vitro) | ubiquitin C | 0.489 |
CDV3 | NDUFAF2 | ENSP00000264993 | ENSP00000296597 | CDV3 homolog (mouse) | NADH dehydrogenase (ubiquinone) complex I, assembly factor 2; Acts as a molecular chaperone for mitochondrial complex I assembly | 0.644 |
CDV3 | UBC | ENSP00000264993 | ENSP00000344818 | CDV3 homolog (mouse) | ubiquitin C | 0.483 |
MAX | MYC | ENSP00000351490 | ENSP00000367207 | MYC associated factor X; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5’-CAC[GA]TG-3’. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 ’Lys-9’ histone methyltransferase activity | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | 0.999 |
MAX | NDUFAF2 | ENSP00000351490 | ENSP00000296597 | MYC associated factor X; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5’-CAC[GA]TG-3’. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 ’Lys-9’ histone methyltransferase activity | NADH dehydrogenase (ubiquinone) complex I, assembly factor 2; Acts as a molecular chaperone for mitochondrial complex I assembly | 0.900 |
MYC | MAX | ENSP00000367207 | ENSP00000351490 | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | MYC associated factor X; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5’-CAC[GA]TG-3’. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 ’Lys-9’ histone methyltransferase activity | 0.999 |
MYC | NDUFAF2 | ENSP00000367207 | ENSP00000296597 | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | NADH dehydrogenase (ubiquinone) complex I, assembly factor 2; Acts as a molecular chaperone for mitochondrial complex I assembly | 0.982 |
MYC | UBC | ENSP00000367207 | ENSP00000344818 | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | ubiquitin C | 0.999 |
NDUFAF2 | ACOT13 | ENSP00000296597 | ENSP00000230048 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 2; Acts as a molecular chaperone for mitochondrial complex I assembly | acyl-CoA thioesterase 13; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3- hydroxyphenylacetyl-CoA and 3,4-dihydrohyphenylacetyl-CoA (in vitro) | 0.644 |
NDUFAF2 | CDV3 | ENSP00000296597 | ENSP00000264993 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 2; Acts as a molecular chaperone for mitochondrial complex I assembly | CDV3 homolog (mouse) | 0.644 |
NDUFAF2 | MAX | ENSP00000296597 | ENSP00000351490 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 2; Acts as a molecular chaperone for mitochondrial complex I assembly | MYC associated factor X; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5’-CAC[GA]TG-3’. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 ’Lys-9’ histone methyltransferase activity | 0.900 |
NDUFAF2 | MYC | ENSP00000296597 | ENSP00000367207 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 2; Acts as a molecular chaperone for mitochondrial complex I assembly | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | 0.982 |
NDUFAF2 | PPIF | ENSP00000296597 | ENSP00000225174 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 2; Acts as a molecular chaperone for mitochondrial complex I assembly | peptidylprolyl isomerase F; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probablity of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress- i [...] | 0.644 |
NDUFAF2 | RPS24 | ENSP00000296597 | ENSP00000414321 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 2; Acts as a molecular chaperone for mitochondrial complex I assembly | ribosomal protein S24; Required for processing of pre-rRNA and maturation of 40S ribosomal subunits | 0.644 |
NDUFAF2 | RPS26 | ENSP00000296597 | ENSP00000348849 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 2; Acts as a molecular chaperone for mitochondrial complex I assembly | ribosomal protein S26 | 0.644 |
NDUFAF2 | SON | ENSP00000296597 | ENSP00000348984 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 2; Acts as a molecular chaperone for mitochondrial complex I assembly | SON DNA binding protein | 0.644 |
NDUFAF2 | SUGP2 | ENSP00000296597 | ENSP00000337926 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 2; Acts as a molecular chaperone for mitochondrial complex I assembly | SURP and G patch domain containing 2; May play a role in mRNA splicing (Potential) | 0.644 |
NDUFAF2 | UBC | ENSP00000296597 | ENSP00000344818 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 2; Acts as a molecular chaperone for mitochondrial complex I assembly | ubiquitin C | 0.483 |
PPIF | NDUFAF2 | ENSP00000225174 | ENSP00000296597 | peptidylprolyl isomerase F; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probablity of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress- i [...] | NADH dehydrogenase (ubiquinone) complex I, assembly factor 2; Acts as a molecular chaperone for mitochondrial complex I assembly | 0.644 |