Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | DEFB129 | defensin, beta 129; Has antibacterial activity (Potential) (183 aa) | ||
 | DEFA4 | defensin, alpha 4, corticostatin; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production (97 aa) | ||
 | DEFA6 | defensin, alpha 6, Paneth cell-specific; Has very low antimicrobial activity against Gram- negative and Gram-positive bacteria. May protect cells against infection with HIV-1 (100 aa) | ||
 | DEFB1 | defensin, beta 1; Has bactericidal activity (By similarity) (68 aa) | ||
 | DEFB114 | defensin, beta 114; Has antibacterial activity (By similarity) (69 aa) | ||
 | DEFB112 | defensin, beta 112; Has antibacterial activity (By similarity) (113 aa) | ||
 | DEFB124 | defensin, beta 124; Has antibacterial activity (Potential) (71 aa) | ||
 | DEFA3 | defensin, alpha 3, neutrophil-specific; Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane (94 aa) | ||
 | DEFB108B | defensin, beta 108B; Has antibacterial activity (By similarity) (73 aa) | ||
 | DEFB128 | defensin, beta 128; Has antibacterial activity (Potential) (93 aa) | ||
 | DEFB131 | defensin, beta 131; Has antibacterial activity (Potential) (70 aa) | ||
 | DEFB110 | defensin, beta 110 locus; Has antibacterial activity (By similarity) (67 aa) | ||
 | DEFB123 | defensin, beta 123; Has antibacterial activity (Potential) (67 aa) | ||
 | DEFB119 | defensin, beta 119; Has antibacterial activity (Potential) (88 aa) | ||
 | DEFB135 | defensin, beta 135; Has antibacterial activity (Potential) (77 aa) | ||
 | DEFB136 | defensin, beta 136; Has antibacterial activity (Potential) (78 aa) | ||
 | DEFB132 | defensin, beta 132; Has antibacterial activity (Potential) (95 aa) | ||
 | DEFB127 | defensin, beta 127; Has antibacterial activity (Potential) (99 aa) | ||
 | DEFB126 | defensin, beta 126; Has antibacterial activity (Potential) (111 aa) | ||
 | DEFB125 | defensin, beta 125; Has antibacterial activity (Potential) (156 aa) | ||
 | DEFB113 | defensin, beta 113; Has antibacterial activity (By similarity) (82 aa) | ||
 | DEFB133 | defensin, beta 133; Has antibacterial activity (Potential) (61 aa) | ||
 | DEFB116 | defensin, beta 116; Has antibacterial activity (By similarity) (102 aa) | ||
 | DEFB115 | defensin, beta 115; Has antibacterial activity (By similarity) (88 aa) | ||
 | DEFB121 | defensin, beta 121; Has antibacterial activity (Potential) (76 aa) | ||
 | DEFB134 | defensin, beta 134; Has antibacterial activity (Potential) (66 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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