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STRINGSTRING
POP7 POP7 EIF4EBP2 EIF4EBP2 GNB2L1 GNB2L1 RPP25L RPP25L UBC UBC ARHGEF2 ARHGEF2 PNMA1 PNMA1 MID2 MID2 WDR31 WDR31 EIF4EBP3 EIF4EBP3 RPGRIP1 RPGRIP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
MID2midline 2 (735 aa)
RPP25Lribonuclease P/MRP 25kDa subunit-like; May be a component of ribonuclease P or MRP (163 aa)
POP7processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae); Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends (140 aa)
EIF4EBP3eukaryotic translation initiation factor 4E binding protein 3; Regulates eIF4E activity by preventing its assembly into the eIF4F complex (100 aa)
PNMA1paraneoplastic Ma antigen 1 (353 aa)
UBCubiquitin C (685 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor (GEF) 2; Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed-9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras- GTPases. Forms an intracellular sensing sys [...] (986 aa)
EIF4EBP2eukaryotic translation initiation factor 4E binding protein 2; Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway (120 aa)
WDR31WD repeat domain 31 (367 aa)
RPGRIP1retinitis pigmentosa GTPase regulator interacting protein 1; Essential for RPGR function and is also required for normal disk morphogenesis (By similarity) (1286 aa)
GNB2L1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 (317 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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