| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACAA2 | ACAT1 | ENSP00000285093 | ENSP00000265838 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | 0.972 |
| ACAA2 | RTN4 | ENSP00000285093 | ENSP00000337838 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | reticulon 4 | 0.659 |
| ACAA2 | TAX1BP3 | ENSP00000285093 | ENSP00000225525 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | Tax1 (human T-cell leukemia virus type I) binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6 | 0.969 |
| ACAA2 | TMEM65 | ENSP00000285093 | ENSP00000297632 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | transmembrane protein 65 | 0.972 |
| ACAT1 | ACAA2 | ENSP00000265838 | ENSP00000285093 | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | 0.972 |
| ACAT1 | TMEM65 | ENSP00000265838 | ENSP00000297632 | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | transmembrane protein 65 | 0.644 |
| COX15 | NDUFS6 | ENSP00000016171 | ENSP00000274137 | cytochrome c oxidase assembly homolog 15 (yeast); May be involved in the biosynthesis of heme A | NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase); Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone | 0.909 |
| ELAVL1 | S100A10 | ENSP00000385269 | ENSP00000357799 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | S100 calcium binding protein A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine- specific kinase | 0.644 |
| NDUFS6 | COX15 | ENSP00000274137 | ENSP00000016171 | NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase); Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone | cytochrome c oxidase assembly homolog 15 (yeast); May be involved in the biosynthesis of heme A | 0.909 |
| NDUFS6 | TMEM65 | ENSP00000274137 | ENSP00000297632 | NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase); Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone | transmembrane protein 65 | 0.644 |
| RTN4 | ACAA2 | ENSP00000337838 | ENSP00000285093 | reticulon 4 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | 0.659 |
| RTN4 | TMEM65 | ENSP00000337838 | ENSP00000297632 | reticulon 4 | transmembrane protein 65 | 0.909 |
| S100A10 | ELAVL1 | ENSP00000357799 | ENSP00000385269 | S100 calcium binding protein A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine- specific kinase | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | 0.644 |
| S100A10 | SRPRB | ENSP00000357799 | ENSP00000418401 | S100 calcium binding protein A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine- specific kinase | signal recognition particle receptor, B subunit; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity) | 0.649 |
| S100A10 | TMEM65 | ENSP00000357799 | ENSP00000297632 | S100 calcium binding protein A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine- specific kinase | transmembrane protein 65 | 0.809 |
| SRPRB | S100A10 | ENSP00000418401 | ENSP00000357799 | signal recognition particle receptor, B subunit; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity) | S100 calcium binding protein A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine- specific kinase | 0.649 |
| SRPRB | TMEM65 | ENSP00000418401 | ENSP00000297632 | signal recognition particle receptor, B subunit; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity) | transmembrane protein 65 | 0.644 |
| TAX1BP3 | ACAA2 | ENSP00000225525 | ENSP00000285093 | Tax1 (human T-cell leukemia virus type I) binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | 0.969 |
| TAX1BP3 | TMEM65 | ENSP00000225525 | ENSP00000297632 | Tax1 (human T-cell leukemia virus type I) binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6 | transmembrane protein 65 | 0.926 |
| TMEM65 | ACAA2 | ENSP00000297632 | ENSP00000285093 | transmembrane protein 65 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | 0.972 |
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