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KRTAP4-2 KRTAP4-2 CYP39A1 CYP39A1 SIGMAR1 SIGMAR1 PTGIS PTGIS LBR LBR DHCR7 DHCR7 CYP7B1 CYP7B1 HSD3B7 HSD3B7 TM7SF2 TM7SF2 C14orf1 C14orf1 AGMO AGMO SQLE SQLE SC5DL SC5DL CYP51A1 CYP51A1 C5orf4 C5orf4 MCM7 MCM7 MSMO1 MSMO1 CH25H CH25H HSD17B7 HSD17B7 UBC UBC LSS LSS FDFT1 FDFT1 AKR1D1 AKR1D1 CYP8B1 CYP8B1 CYP7A1 CYP7A1 MDN1 MDN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
CYP51A1cytochrome P450, family 51, subfamily A, polypeptide 1 (509 aa)
FDFT1farnesyl-diphosphate farnesyltransferase 1 (417 aa)
AKR1D1aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase); Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates (326 aa)
PTGISprostaglandin I2 (prostacyclin) synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2) (500 aa)
HSD17B7hydroxysteroid (17-beta) dehydrogenase 7; Responsible for the reduction of the keto group on the C-3 of sterols (341 aa)
C14orf1chromosome 14 open reading frame 1 (140 aa)
MSMO1methylsterol monooxygenase 1 (293 aa)
SC5DLsterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol (299 aa)
SQLEsqualene epoxidase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway (574 aa)
LBRlamin B receptor; Anchors the lamina and the heterochromatin to the inner nuclear membrane (615 aa)
CYP39A1cytochrome P450, family 39, subfamily A, polypeptide 1; Involved in the bile acid metabolism. Has a preference for 24-hydroxycholesterol, and converts it into a 7-alpha- hydroxylated product (469 aa)
SIGMAR1sigma non-opioid intracellular receptor 1 (223 aa)
TM7SF2transmembrane 7 superfamily member 2; Involved in the conversion of lanosterol to cholesterol (418 aa)
HSD3B7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (369 aa)
CYP7A1cytochrome P450, family 7, subfamily A, polypeptide 1; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis (504 aa)
MCM7minichromosome maintenance complex component 7; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute dif [...] (719 aa)
CYP7B1cytochrome P450, family 7, subfamily B, polypeptide 1 (506 aa)
CYP8B1cytochrome P450, family 8, subfamily B, polypeptide 1; Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids (501 aa)
C5orf4chromosome 5 open reading frame 4 (333 aa)
AGMOalkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes (445 aa)
UBCubiquitin C (685 aa)
DHCR77-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC) (475 aa)
LSSlanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus (732 aa)
MDN1MDN1, midasin homolog (yeast); Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (By similarity) (5596 aa)
CH25Hcholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25- hydroxycholesterol by macrophages may play a role in Leydig cell differentiation (272 aa)
KRTAP4-2keratin associated protein 4-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins (136 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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