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HINFP HINFP DIS3 DIS3 RPUSD4 RPUSD4 RNMTL1 RNMTL1 DIS3L DIS3L CYC1 CYC1 IKBIP IKBIP HELZ2 HELZ2 DIS3L2 DIS3L2 MRPL17 MRPL17 ICT1 ICT1 SYNCRIP SYNCRIP ZMYM3 ZMYM3 UBC UBC CDR2 CDR2 QRICH1 QRICH1 ZMYM4 ZMYM4 PSMC1 PSMC1 ZMYM2 ZMYM2 ZMYM6 ZMYM6 SNRPF SNRPF SUMO1 SUMO1 PSMD4 PSMD4 CDR2L CDR2L FGFR1OP2 FGFR1OP2 SLMAP SLMAP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
FGFR1OP2FGFR1 oncogene partner 2; May be involved in wound healing pathway (By similarity) (253 aa)
PSMC1proteasome (prosome, macropain) 26S subunit, ATPase, 1; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (440 aa)
SNRPFsmall nuclear ribonucleoprotein polypeptide F; Appears to function in the U7 snRNP complex that is involved in histone 3’-end processing. Associated with snRNP U1, U2, U4/U6 and U5 (86 aa)
CDR2cerebellar degeneration-related protein 2, 62kDa (454 aa)
MRPL17mitochondrial ribosomal protein L17 (175 aa)
SLMAPsarcolemma associated protein (811 aa)
RPUSD4RNA pseudouridylate synthase domain containing 4 (377 aa)
IKBIPIKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function (377 aa)
ICT1immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (206 aa)
RNMTL1RNA methyltransferase like 1; Probable RNA methyltransferase (By similarity) (420 aa)
DIS3L2DIS3 mitotic control homolog (S. cerevisiae)-like 2; Ribonuclease that plays a critical role in RNA metabolism. It is essential for correct mitosis, and negatively regulates cell proliferation (885 aa)
CYC1cytochrome c-1; This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain (325 aa)
HINFPhistone H4 transcription factor; Transcriptional repressor that binds to the consensus sequence 5’-CGGACGTT-3’ and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter (517 aa)
DIS3LDIS3 mitotic control homolog (S. cerevisiae)-like; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3’ untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA (1054 aa)
ZMYM3zinc finger, MYM-type 3; Plays a role in the regulation of cell morphology and cytoskeletal organization (1370 aa)
ZMYM4zinc finger, MYM-type 4; Plays a role in the regulation of cell morphology and cytoskeletal organization (1548 aa)
CDR2Lcerebellar degeneration-related protein 2-like (465 aa)
UBCubiquitin C (685 aa)
ZMYM6zinc finger, MYM-type 6 (1325 aa)
QRICH1glutamine-rich 1 (776 aa)
PSMD4proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion (377 aa)
SYNCRIPsynaptotagmin binding, cytoplasmic RNA interacting protein (623 aa)
DIS3DIS3 mitotic control homolog (S. cerevisiae) (958 aa)
ZMYM2zinc finger, MYM-type 2 (1377 aa)
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. [...] (101 aa)
HELZ2helicase with zinc finger 2, transcriptional coactivator; Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA (2649 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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