node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C9orf16 | IKBIP | ENSP00000362085 | ENSP00000299157 | chromosome 9 open reading frame 16 | IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function | 0.548 |
ELAVL1 | HNRNPH1 | ENSP00000385269 | ENSP00000349168 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | heterogeneous nuclear ribonucleoprotein H1 (H); This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG) | 0.565 |
ELAVL1 | MYOG | ENSP00000385269 | ENSP00000241651 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | myogenin (myogenic factor 4); Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein | 0.851 |
ELAVL1 | SRSF5 | ENSP00000385269 | ENSP00000377892 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | serine/arginine-rich splicing factor 5; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites | 0.705 |
ELAVL1 | UBC | ENSP00000385269 | ENSP00000344818 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | ubiquitin C | 0.998 |
HNRNPH1 | ELAVL1 | ENSP00000349168 | ENSP00000385269 | heterogeneous nuclear ribonucleoprotein H1 (H); This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG) | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | 0.565 |
HNRNPH1 | IKBIP | ENSP00000349168 | ENSP00000299157 | heterogeneous nuclear ribonucleoprotein H1 (H); This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG) | IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function | 0.644 |
HNRNPH1 | SRSF5 | ENSP00000349168 | ENSP00000377892 | heterogeneous nuclear ribonucleoprotein H1 (H); This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG) | serine/arginine-rich splicing factor 5; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites | 0.977 |
HNRNPH1 | SYNCRIP | ENSP00000349168 | ENSP00000358635 | heterogeneous nuclear ribonucleoprotein H1 (H); This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG) | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.959 |
HNRNPH1 | UBC | ENSP00000349168 | ENSP00000344818 | heterogeneous nuclear ribonucleoprotein H1 (H); This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG) | ubiquitin C | 0.995 |
IKBIP | C9orf16 | ENSP00000299157 | ENSP00000362085 | IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function | chromosome 9 open reading frame 16 | 0.548 |
IKBIP | HNRNPH1 | ENSP00000299157 | ENSP00000349168 | IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function | heterogeneous nuclear ribonucleoprotein H1 (H); This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG) | 0.644 |
IKBIP | NDUFB6 | ENSP00000299157 | ENSP00000369176 | IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone | 0.644 |
IKBIP | OXA1L | ENSP00000299157 | ENSP00000285848 | IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function | oxidase (cytochrome c) assembly 1-like; Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria | 0.644 |
IKBIP | PDCD6 | ENSP00000299157 | ENSP00000264933 | IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function | programmed cell death 6; Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)- regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity | 0.644 |
IKBIP | RPUSD4 | ENSP00000299157 | ENSP00000298317 | IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function | RNA pseudouridylate synthase domain containing 4 | 0.974 |
IKBIP | SFXN2 | ENSP00000299157 | ENSP00000358909 | IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function | sideroflexin 2; Potential iron transporter | 0.644 |
IKBIP | SRSF5 | ENSP00000299157 | ENSP00000377892 | IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function | serine/arginine-rich splicing factor 5; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites | 0.644 |
IKBIP | SYNCRIP | ENSP00000299157 | ENSP00000358635 | IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.644 |
IKBIP | TMED4 | ENSP00000299157 | ENSP00000404042 | IKBKB interacting protein; Target of p53/TP53 with pro-apoptotic function | transmembrane emp24 protein transport domain containing 4; Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity) | 0.644 |