| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C1R | C1S | ENSP00000290575 | ENSP00000328173 | complement component 1, r subcomponent | complement component 1, s subcomponent | 0.985 |
| C1R | C3 | ENSP00000290575 | ENSP00000245907 | complement component 1, r subcomponent | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | 0.716 |
| C1S | C1R | ENSP00000328173 | ENSP00000290575 | complement component 1, s subcomponent | complement component 1, r subcomponent | 0.985 |
| C1S | C3 | ENSP00000328173 | ENSP00000245907 | complement component 1, s subcomponent | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | 0.776 |
| C2 | C3 | ENSP00000299367 | ENSP00000245907 | complement component 2 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | 0.626 |
| C2 | C5 | ENSP00000299367 | ENSP00000223642 | complement component 2 | complement component 5; Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled | 0.592 |
| C2 | MASP1 | ENSP00000299367 | ENSP00000296280 | complement component 2 | mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) | 0.658 |
| C2 | PSMA4 | ENSP00000299367 | ENSP00000044462 | complement component 2 | proteasome (prosome, macropain) subunit, alpha type, 4; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity) | 0.576 |
| C3 | C1R | ENSP00000245907 | ENSP00000290575 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | complement component 1, r subcomponent | 0.716 |
| C3 | C1S | ENSP00000245907 | ENSP00000328173 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | complement component 1, s subcomponent | 0.776 |
| C3 | C2 | ENSP00000245907 | ENSP00000299367 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | complement component 2 | 0.626 |
| C3 | C5 | ENSP00000245907 | ENSP00000223642 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | complement component 5; Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled | 0.960 |
| C3 | MASP1 | ENSP00000245907 | ENSP00000296280 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) | 0.852 |
| C3 | MASP2 | ENSP00000245907 | ENSP00000383690 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | mannan-binding lectin serine peptidase 2 | 0.723 |
| C5 | C2 | ENSP00000223642 | ENSP00000299367 | complement component 5; Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled | complement component 2 | 0.592 |
| C5 | C3 | ENSP00000223642 | ENSP00000245907 | complement component 5; Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | 0.960 |
| MASP1 | C2 | ENSP00000296280 | ENSP00000299367 | mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) | complement component 2 | 0.658 |
| MASP1 | C3 | ENSP00000296280 | ENSP00000245907 | mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | 0.852 |
| MASP1 | MASP2 | ENSP00000296280 | ENSP00000383690 | mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) | mannan-binding lectin serine peptidase 2 | 0.957 |
| MASP2 | C3 | ENSP00000383690 | ENSP00000245907 | mannan-binding lectin serine peptidase 2 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | 0.723 |
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