Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | MRPS10 | mitochondrial ribosomal protein S10 (201 aa) | ||
 | MRPS35 | mitochondrial ribosomal protein S35 (323 aa) | ||
 | MRPS2 | mitochondrial ribosomal protein S2 (296 aa) | ||
 | PTCD3 | pentatricopeptide repeat domain 3; Mitochondrial RNA-binding protein that has a role in mitochondrial translation (689 aa) | ||
 | MRPS18B | mitochondrial ribosomal protein S18B (258 aa) | ||
 | MRPS5 | mitochondrial ribosomal protein S5 (430 aa) | ||
 | MRPS17 | mitochondrial ribosomal protein S17 (130 aa) | ||
 | RPS23 | ribosomal protein S23 (143 aa) | ||
 | A2ML1 | alpha-2-macroglobulin-like 1; Is able to inhibit all four classes of proteinases by a unique ’trapping’ mechanism. This protein has a peptide stretch, called the ’bait region’ which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates [...] (1454 aa) | ||
 | MRPS22 | mitochondrial ribosomal protein S22 (360 aa) | ||
 | MRPS21 | mitochondrial ribosomal protein S21 (87 aa) | ||
 | MRPS31 | mitochondrial ribosomal protein S31 (395 aa) | ||
 | MRPS11 | mitochondrial ribosomal protein S11 (194 aa) | ||
 | MRPS24 | mitochondrial ribosomal protein S24 (167 aa) | ||
 | MRPS23 | mitochondrial ribosomal protein S23 (190 aa) | ||
 | MRPS33 | mitochondrial ribosomal protein S33 (106 aa) | ||
 | DAP3 | death associated protein 3; Involved in mediating interferon-gamma-induced cell death (398 aa) | ||
 | CHCHD1 | coiled-coil-helix-coiled-coil-helix domain containing 1 (118 aa) | ||
 | MRPS16 | mitochondrial ribosomal protein S16 (137 aa) | ||
 | MRPS15 | mitochondrial ribosomal protein S15 (257 aa) | ||
 | MRPS26 | mitochondrial ribosomal protein S26 (205 aa) | ||
 | DENND4C | DENN/MADD domain containing 4C (1673 aa) | ||
 | MRPS34 | mitochondrial ribosomal protein S34 (218 aa) | ||
 | S17mt | 28S ribosomal protein S17, mitochondrial; HCG1984214, isoform CRA_a (225 aa) | ||
 | DENND4A | DENN/MADD domain containing 4A; Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. According to PubMed-8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter (1906 aa) | ||
 | MRPS14 | mitochondrial ribosomal protein S14 (128 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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