amyloid beta (A4) precursor protein

calcium/calmodulin-dependent protein kinase II beta

amyloid beta (A4) precursor protein

cell division cycle 42 (GTP binding protein, 25kDa); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration

amyloid beta (A4) precursor protein

FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...]

amyloid beta (A4) precursor protein

polo-like kinase 1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55 [...]

amyloid beta (A4) precursor protein

v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...]

amyloid beta (A4) precursor protein

ubiquitin C

ADP-ribosylation factor-like 8A; May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity)

ADP-ribosylation factor-like 8B; May play a role in lysosome motility (PubMed-16537643). May play a role in chromosome segregation (PubMed-15331635)

ADP-ribosylation factor-like 8A; May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity)

aurora kinase C; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at ’Ser-10’ and ’Ser-28’. Phosphorylates TA [...]

ADP-ribosylation factor-like 8A; May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity)

budding uninhibited by benzimidazoles 1 homolog beta (yeast)

ADP-ribosylation factor-like 8A; May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity)

cell division cycle 42 (GTP binding protein, 25kDa); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration

ADP-ribosylation factor-like 8A; May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity)

cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated

ADP-ribosylation factor-like 8A; May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity)

centromere protein V; Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis

ADP-ribosylation factor-like 8A; May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity)

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1; Processively dephosphorylates ’Ser-2’ and ’Ser-5’ of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation

ADP-ribosylation factor-like 8A; May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity)

GTP binding protein overexpressed in skeletal muscle; Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity

ADP-ribosylation factor-like 8A; May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity)

KIAA1383; Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis

ADP-ribosylation factor-like 8A; May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity)

olfactory receptor, family 2, subfamily A, member 4; Odorant receptor (Potential)

ADP-ribosylation factor-like 8A; May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity)

plakophilin 4; Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques

ADP-ribosylation factor-like 8A; May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity)

polo-like kinase 1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55 [...]

ADP-ribosylation factor-like 8A; May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity)

Rac GTPase activating protein 1; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase acti [...]

ADP-ribosylation factor-like 8A; May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity)

regulator of chromosome condensation 2; Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1