node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CIAO1 | DNA2 | ENSP00000418287 | ENSP00000382133 | cytosolic iron-sulfur protein assembly 1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation | DNA replication helicase 2 homolog (yeast); Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1- flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5’-end resection of DNA during double- strand break (DSB) repair- recruited by BLM and mediates the cleavage of 5’-ssDNA, while the 3’-ssDNA cleavage is prev [...] | 0.477 |
CIAO1 | FAM96A | ENSP00000418287 | ENSP00000300030 | cytosolic iron-sulfur protein assembly 1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation | family with sequence similarity 96, member A; May play a role in chromosome segregation through establishment of sister chromatid cohesion (By similarity) | 0.994 |
CIAO1 | MMS19 | ENSP00000418287 | ENSP00000359818 | cytosolic iron-sulfur protein assembly 1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation | MMS19 nucleotide excision repair homolog (S. cerevisiae) | 0.999 |
CIAO1 | NARF | ENSP00000418287 | ENSP00000309899 | cytosolic iron-sulfur protein assembly 1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation | nuclear prelamin A recognition factor | 0.478 |
CIAO1 | NARFL | ENSP00000418287 | ENSP00000251588 | cytosolic iron-sulfur protein assembly 1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation | nuclear prelamin A recognition factor-like; Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect | 0.994 |
CIAO1 | UBC | ENSP00000418287 | ENSP00000344818 | cytosolic iron-sulfur protein assembly 1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation | ubiquitin C | 0.874 |
DNA2 | CIAO1 | ENSP00000382133 | ENSP00000418287 | DNA replication helicase 2 homolog (yeast); Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1- flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5’-end resection of DNA during double- strand break (DSB) repair- recruited by BLM and mediates the cleavage of 5’-ssDNA, while the 3’-ssDNA cleavage is prev [...] | cytosolic iron-sulfur protein assembly 1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation | 0.477 |
DNA2 | FAM96A | ENSP00000382133 | ENSP00000300030 | DNA replication helicase 2 homolog (yeast); Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1- flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5’-end resection of DNA during double- strand break (DSB) repair- recruited by BLM and mediates the cleavage of 5’-ssDNA, while the 3’-ssDNA cleavage is prev [...] | family with sequence similarity 96, member A; May play a role in chromosome segregation through establishment of sister chromatid cohesion (By similarity) | 0.525 |
DNA2 | MMS19 | ENSP00000382133 | ENSP00000359818 | DNA replication helicase 2 homolog (yeast); Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1- flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5’-end resection of DNA during double- strand break (DSB) repair- recruited by BLM and mediates the cleavage of 5’-ssDNA, while the 3’-ssDNA cleavage is prev [...] | MMS19 nucleotide excision repair homolog (S. cerevisiae) | 0.574 |
DNA2 | TDRD3 | ENSP00000382133 | ENSP00000440190 | DNA replication helicase 2 homolog (yeast); Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1- flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5’-end resection of DNA during double- strand break (DSB) repair- recruited by BLM and mediates the cleavage of 5’-ssDNA, while the 3’-ssDNA cleavage is prev [...] | tudor domain containing 3; Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator- recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine- methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins | 0.598 |
DNA2 | TOP3B | ENSP00000382133 | ENSP00000349705 | DNA replication helicase 2 homolog (yeast); Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1- flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5’-end resection of DNA during double- strand break (DSB) repair- recruited by BLM and mediates the cleavage of 5’-ssDNA, while the 3’-ssDNA cleavage is prev [...] | topoisomerase (DNA) III beta; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoi [...] | 0.516 |
DNA2 | UBC | ENSP00000382133 | ENSP00000344818 | DNA replication helicase 2 homolog (yeast); Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1- flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5’-end resection of DNA during double- strand break (DSB) repair- recruited by BLM and mediates the cleavage of 5’-ssDNA, while the 3’-ssDNA cleavage is prev [...] | ubiquitin C | 0.807 |
DNAJB6 | UBC | ENSP00000262177 | ENSP00000344818 | DnaJ (Hsp40) homolog, subfamily B, member 6 | ubiquitin C | 0.963 |
ELP2 | FAM96A | ENSP00000414851 | ENSP00000300030 | elongator acetyltransferase complex subunit 2 | family with sequence similarity 96, member A; May play a role in chromosome segregation through establishment of sister chromatid cohesion (By similarity) | 0.447 |
ELP2 | UBC | ENSP00000414851 | ENSP00000344818 | elongator acetyltransferase complex subunit 2 | ubiquitin C | 0.908 |
FAM96A | CIAO1 | ENSP00000300030 | ENSP00000418287 | family with sequence similarity 96, member A; May play a role in chromosome segregation through establishment of sister chromatid cohesion (By similarity) | cytosolic iron-sulfur protein assembly 1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation | 0.994 |
FAM96A | DNA2 | ENSP00000300030 | ENSP00000382133 | family with sequence similarity 96, member A; May play a role in chromosome segregation through establishment of sister chromatid cohesion (By similarity) | DNA replication helicase 2 homolog (yeast); Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1- flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5’-end resection of DNA during double- strand break (DSB) repair- recruited by BLM and mediates the cleavage of 5’-ssDNA, while the 3’-ssDNA cleavage is prev [...] | 0.525 |
FAM96A | ELP2 | ENSP00000300030 | ENSP00000414851 | family with sequence similarity 96, member A; May play a role in chromosome segregation through establishment of sister chromatid cohesion (By similarity) | elongator acetyltransferase complex subunit 2 | 0.447 |
FAM96A | MMS19 | ENSP00000300030 | ENSP00000359818 | family with sequence similarity 96, member A; May play a role in chromosome segregation through establishment of sister chromatid cohesion (By similarity) | MMS19 nucleotide excision repair homolog (S. cerevisiae) | 0.920 |
FAM96A | NARF | ENSP00000300030 | ENSP00000309899 | family with sequence similarity 96, member A; May play a role in chromosome segregation through establishment of sister chromatid cohesion (By similarity) | nuclear prelamin A recognition factor | 0.823 |