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RGPD6 RGPD6 TMEM194A TMEM194A RGPD8 RGPD8 RGPD1 RGPD1 RGPD2 RGPD2 RRM2B RRM2B RRM2 RRM2 UBE2I UBE2I RANBP1 RANBP1 RAN RAN RANGAP1 RANGAP1 NXF2 NXF2 KPNB1 KPNB1 NXF2B NXF2B RGPD4 RGPD4 RGPD3 RGPD3 NXT1 NXT1 NXF1 NXF1 RANBP2 RANBP2 RGPD5 RGPD5 NXF3 NXF3 NXT2 NXT2 NXF5 NXF5 VAPA VAPA ICK ICK VAPB VAPB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
RGPD5RANBP2-like and GRIP domain containing 5 (1765 aa)
NXT2nuclear transport factor 2-like export factor 2 (197 aa)
RRM2Bribonucleotide reductase M2 B (TP53 inducible) (351 aa)
NXT1NTF2-like export factor 1; Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (140 aa)
ICKintestinal cell (MAK-like) kinase; May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity) (632 aa)
RANBP2RAN binding protein 2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at ’Lys-490’ which is essential for the proper assembly of PML-NB (3224 aa)
KPNB1karyopherin (importin) beta 1; Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleopl [...] (876 aa)
NXF1nuclear RNA export factor 1; Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (619 aa)
TMEM194Atransmembrane protein 194A (444 aa)
RGPD8RANBP2-like and GRIP domain containing 8 (1765 aa)
UBE2Iubiquitin-conjugating enzyme E2I; Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly- SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at ’Lys-386’ (By similarity) (158 aa)
RANBP1RAN binding protein 1; Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane (201 aa)
RGPD6RANBP2-like and GRIP domain containing 6 (1765 aa)
NXF2nuclear RNA export factor 2 (626 aa)
VAPAVAMP (vesicle-associated membrane protein)-associated protein A, 33kDa; May play a role in vesicle trafficking (294 aa)
RANGAP1Ran GTPase activating protein 1; GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state (587 aa)
RRM2ribonucleotide reductase M2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling (449 aa)
NXF2Bnuclear RNA export factor 2B; Involved in the export of mRNA from the nucleus to the cytoplasm (626 aa)
RANRAN, member RAS oncogene family (216 aa)
NXF3nuclear RNA export factor 3; May function as a tissue-specific nuclear mRNA export factor (531 aa)
RGPD2RANBP2-like and GRIP domain containing 2 (1756 aa)
RGPD1RANBP2-like and GRIP domain containing 1 (1756 aa)
RGPD3RANBP2-like and GRIP domain containing 3 (1758 aa)
RGPD4RANBP2-like and GRIP domain containing 4 (1758 aa)
VAPBVAMP (vesicle-associated membrane protein)-associated protein B and C; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation (243 aa)
NXF5nuclear RNA export factor 5 (365 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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