node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANK1 | ANK2 | ENSP00000265709 | ENSP00000349588 | ankyrin 1, erythrocytic | ankyrin 2, neuronal; In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions (By similarity). Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase and InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes. Required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in the inner se [...] | 0.904 |
ANK1 | EPB41 | ENSP00000265709 | ENSP00000345259 | ankyrin 1, erythrocytic | erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) | 0.429 |
ANK1 | EPB42 | ENSP00000265709 | ENSP00000300215 | ankyrin 1, erythrocytic | erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties | 0.804 |
ANK1 | SLC4A1 | ENSP00000265709 | ENSP00000262418 | ankyrin 1, erythrocytic | solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group); Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1-1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin | 0.930 |
ANK1 | SPTAN1 | ENSP00000265709 | ENSP00000361824 | ankyrin 1, erythrocytic | spectrin, alpha, non-erythrocytic 1 | 0.961 |
ANK2 | ANK1 | ENSP00000349588 | ENSP00000265709 | ankyrin 2, neuronal; In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions (By similarity). Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase and InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes. Required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in the inner se [...] | ankyrin 1, erythrocytic | 0.904 |
ANK2 | EPB42 | ENSP00000349588 | ENSP00000300215 | ankyrin 2, neuronal; In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions (By similarity). Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase and InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes. Required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in the inner se [...] | erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties | 0.566 |
ANK2 | SPTAN1 | ENSP00000349588 | ENSP00000361824 | ankyrin 2, neuronal; In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions (By similarity). Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase and InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes. Required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in the inner se [...] | spectrin, alpha, non-erythrocytic 1 | 0.934 |
BLOC1S4 | EPB42 | ENSP00000318128 | ENSP00000300215 | biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking | erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties | 0.576 |
CD47 | EPB42 | ENSP00000355361 | ENSP00000300215 | CD47 molecule; Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integr [...] | erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties | 0.670 |
EPB41 | ANK1 | ENSP00000345259 | ENSP00000265709 | erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) | ankyrin 1, erythrocytic | 0.429 |
EPB41 | EPB42 | ENSP00000345259 | ENSP00000300215 | erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) | erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties | 0.773 |
EPB41 | EPB49 | ENSP00000345259 | ENSP00000265800 | erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) | erythrocyte membrane protein band 4.9 (dematin); Actin-bundling protein. May function in mitogen- activated protein kinase pathway | 0.563 |
EPB41 | SLC4A1 | ENSP00000345259 | ENSP00000262418 | erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) | solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group); Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1-1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin | 0.859 |
EPB41 | SPTAN1 | ENSP00000345259 | ENSP00000361824 | erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) | spectrin, alpha, non-erythrocytic 1 | 0.820 |
EPB42 | ANK1 | ENSP00000300215 | ENSP00000265709 | erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties | ankyrin 1, erythrocytic | 0.804 |
EPB42 | ANK2 | ENSP00000300215 | ENSP00000349588 | erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties | ankyrin 2, neuronal; In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions (By similarity). Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase and InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes. Required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in the inner se [...] | 0.566 |
EPB42 | BLOC1S4 | ENSP00000300215 | ENSP00000318128 | erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties | biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking | 0.576 |
EPB42 | CD47 | ENSP00000300215 | ENSP00000355361 | erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties | CD47 molecule; Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integr [...] | 0.670 |
EPB42 | EPB41 | ENSP00000300215 | ENSP00000345259 | erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties | erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) | 0.773 |