26 items (Homo sapiens) - STRING network view

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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protein of unknown 3D structure

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second shell of interactors

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

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Your Input:
	PMM1	phosphomannomutase 1; Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain (262 aa)
	AHSA1	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast); Cochaperone that stimulates HSP90 ATPase activity (By similarity). May affect a step in the endoplasmic reticulum to Golgi trafficking (338 aa)
	PGRMC1	progesterone receptor membrane component 1; Receptor for progesterone (By similarity) (195 aa)
	DRG2	developmentally regulated GTP binding protein 2; May play a role in cell proliferation, differentiation and death (364 aa)
	GFPT2	glutamine-fructose-6-phosphate transaminase 2; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins (682 aa)
	EIF2AK4	eukaryotic translation initiation factor 2 alpha kinase 4 (1649 aa)
	IMPACT	Impact homolog (mouse); Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity) (320 aa)
	OLA1	Obg-like ATPase 1 (396 aa)
	ILK	integrin-linked kinase; Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B (452 aa)
	IDH3A	isocitrate dehydrogenase 3 (NAD+) alpha (366 aa)
	GCN1L1	GCN1 general control of amino-acid synthesis 1-like 1 (yeast) (2671 aa)
	UBB	ubiquitin B (229 aa)
	ME2	malic enzyme 2, NAD(+)-dependent, mitochondrial (584 aa)
	EEF1G	eukaryotic translation elongation factor 1 gamma; Probably plays a role in anchoring the complex to other cellular components (437 aa)
	UBC	ubiquitin C (685 aa)
	AHSA2	AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast); Co-chaperone that stimulates HSP90 ATPase activity (By similarity) (137 aa)
	ME3	malic enzyme 3, NADP(+)-dependent, mitochondrial (604 aa)
	CLN3	ceroid-lipofuscinosis, neuronal 3 (438 aa)
	GFPT1	glutamine--fructose-6-phosphate transaminase 1; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins (681 aa)
	ME1	malic enzyme 1, NADP(+)-dependent, cytosolic (572 aa)
	CDC5L	CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (802 aa)
	CCT4	chaperonin containing TCP1, subunit 4 (delta); Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin (539 aa)
	RWDD4	RWD domain containing 4 (188 aa)
	USP19	ubiquitin specific peptidase 19 (1419 aa)
	ENSG00000232856	hsa-mir-3654 (206 aa)
	RWDD1	RWD domain containing 1; Protects DRG2 from proteolytic degradation (By similarity) (243 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHSA1	EEF1G	ENSP00000216479	ENSP00000331901	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast); Cochaperone that stimulates HSP90 ATPase activity (By similarity). May affect a step in the endoplasmic reticulum to Golgi trafficking	eukaryotic translation elongation factor 1 gamma; Probably plays a role in anchoring the complex to other cellular components	0.522
AHSA1	ENSG00000232856	ENSP00000216479	ENSP00000403936	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast); Cochaperone that stimulates HSP90 ATPase activity (By similarity). May affect a step in the endoplasmic reticulum to Golgi trafficking	hsa-mir-3654	0.501
AHSA1	GCN1L1	ENSP00000216479	ENSP00000300648	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast); Cochaperone that stimulates HSP90 ATPase activity (By similarity). May affect a step in the endoplasmic reticulum to Golgi trafficking	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	0.669
AHSA1	UBC	ENSP00000216479	ENSP00000344818	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast); Cochaperone that stimulates HSP90 ATPase activity (By similarity). May affect a step in the endoplasmic reticulum to Golgi trafficking	ubiquitin C	0.858
AHSA2	EEF1G	ENSP00000349525	ENSP00000331901	AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast); Co-chaperone that stimulates HSP90 ATPase activity (By similarity)	eukaryotic translation elongation factor 1 gamma; Probably plays a role in anchoring the complex to other cellular components	0.501
AHSA2	ENSG00000232856	ENSP00000349525	ENSP00000403936	AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast); Co-chaperone that stimulates HSP90 ATPase activity (By similarity)	hsa-mir-3654	0.501
AHSA2	GCN1L1	ENSP00000349525	ENSP00000300648	AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast); Co-chaperone that stimulates HSP90 ATPase activity (By similarity)	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	0.669
CCT4	EEF1G	ENSP00000377958	ENSP00000331901	chaperonin containing TCP1, subunit 4 (delta); Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin	eukaryotic translation elongation factor 1 gamma; Probably plays a role in anchoring the complex to other cellular components	0.483
CCT4	ENSG00000232856	ENSP00000377958	ENSP00000403936	chaperonin containing TCP1, subunit 4 (delta); Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin	hsa-mir-3654	0.477
CCT4	GCN1L1	ENSP00000377958	ENSP00000300648	chaperonin containing TCP1, subunit 4 (delta); Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	0.877
CCT4	ILK	ENSP00000377958	ENSP00000299421	chaperonin containing TCP1, subunit 4 (delta); Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin	integrin-linked kinase; Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B	0.785
CCT4	ME1	ENSP00000377958	ENSP00000358719	chaperonin containing TCP1, subunit 4 (delta); Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin	malic enzyme 1, NADP(+)-dependent, cytosolic	0.707
CCT4	ME2	ENSP00000377958	ENSP00000321070	chaperonin containing TCP1, subunit 4 (delta); Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin	malic enzyme 2, NAD(+)-dependent, mitochondrial	0.707
CCT4	ME3	ENSP00000377958	ENSP00000352657	chaperonin containing TCP1, subunit 4 (delta); Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin	malic enzyme 3, NADP(+)-dependent, mitochondrial	0.707
CCT4	OLA1	ENSP00000377958	ENSP00000284719	chaperonin containing TCP1, subunit 4 (delta); Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin	Obg-like ATPase 1	0.471
CCT4	UBB	ENSP00000377958	ENSP00000304697	chaperonin containing TCP1, subunit 4 (delta); Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin	ubiquitin B	0.465
CCT4	UBC	ENSP00000377958	ENSP00000344818	chaperonin containing TCP1, subunit 4 (delta); Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin	ubiquitin C	0.998
CDC5L	GCN1L1	ENSP00000360532	ENSP00000300648	CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	0.737
CDC5L	UBC	ENSP00000360532	ENSP00000344818	CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing	ubiquitin C	0.740
CLN3	GCN1L1	ENSP00000353073	ENSP00000300648	ceroid-lipofuscinosis, neuronal 3	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	0.783

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