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PMM1 | phosphomannomutase 1; Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain (262 aa) | |||
PGRMC1 | progesterone receptor membrane component 1; Receptor for progesterone (By similarity) (195 aa) | |||
DRG2 | developmentally regulated GTP binding protein 2; May play a role in cell proliferation, differentiation and death (364 aa) | |||
GFPT2 | glutamine-fructose-6-phosphate transaminase 2; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins (682 aa) | |||
EIF2AK4 | eukaryotic translation initiation factor 2 alpha kinase 4 (1649 aa) | |||
PMM2 | phosphomannomutase 2; Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions (By similarity) (246 aa) | |||
IMPACT | Impact homolog (mouse); Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity) (320 aa) | |||
OLA1 | Obg-like ATPase 1 (396 aa) | |||
ILK | integrin-linked kinase; Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B (452 aa) | |||
IDH3A | isocitrate dehydrogenase 3 (NAD+) alpha (366 aa) | |||
GCN1L1 | GCN1 general control of amino-acid synthesis 1-like 1 (yeast) (2671 aa) | |||
UBB | ubiquitin B (229 aa) | |||
ME2 | malic enzyme 2, NAD(+)-dependent, mitochondrial (584 aa) | |||
EEF1G | eukaryotic translation elongation factor 1 gamma; Probably plays a role in anchoring the complex to other cellular components (437 aa) | |||
UBC | ubiquitin C (685 aa) | |||
AHSA2 | AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast); Co-chaperone that stimulates HSP90 ATPase activity (By similarity) (137 aa) | |||
ME3 | malic enzyme 3, NADP(+)-dependent, mitochondrial (604 aa) | |||
CLN3 | ceroid-lipofuscinosis, neuronal 3 (438 aa) | |||
GFPT1 | glutamine--fructose-6-phosphate transaminase 1; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins (681 aa) | |||
ME1 | malic enzyme 1, NADP(+)-dependent, cytosolic (572 aa) | |||
CDC5L | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (802 aa) | |||
CCT4 | chaperonin containing TCP1, subunit 4 (delta); Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin (539 aa) | |||
RWDD4 | RWD domain containing 4 (188 aa) | |||
USP19 | ubiquitin specific peptidase 19 (1419 aa) | |||
ENSG00000232856 | hsa-mir-3654 (206 aa) | |||
RWDD1 | RWD domain containing 1; Protects DRG2 from proteolytic degradation (By similarity) (243 aa) |