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ENSG00000268465 ENSG00000268465 TADA3 TADA3 CYTH3 CYTH3 CTSD CTSD PGA3 PGA3 REN REN KIAA1149 KIAA1149 IQSEC1 IQSEC1 BACE2 BACE2 VPS41 VPS41 PGA4 PGA4 NAPSA NAPSA PCSK4 PCSK4 PSD PSD ARFGEF1 ARFGEF1 PGA5 PGA5 GBF1 GBF1 ARFGEF2 ARFGEF2 PGC PGC FBXO8 FBXO8 CTSE CTSE IQSEC3 IQSEC3 ENSG00000250644 ENSG00000250644 BACE1 BACE1 CYTH4 CYTH4 CYTH2 CYTH2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
PSDpleckstrin and Sec7 domain containing; Guanine nucleotide exchange factor for ARF6. Induces cytoskeletal remodeling (By similarity) (1024 aa)
CTSDcathepsin D; Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease (412 aa)
CYTH4cytohesin 4; Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF through replacement of GDP with GTP (394 aa)
NAPSAnapsin A aspartic peptidase; May be involved in processing of pneumocyte surfactant precursors (420 aa)
ARFGEF1ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited); Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate [...] (1849 aa)
RENrenin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney (406 aa)
IQSEC1IQ motif and Sec7 domain 1; In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin (963 aa)
KIAA1149beta-secretase 1 isoform E (401 aa)
CYTH3cytohesin 3; Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF through replacement of GDP with GTP (399 aa)
PCSK4proprotein convertase subtilisin/kexin type 4; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Plays a role in transcriptional coactivation. May be involved in stabilizing the multiprotein transcription complex (755 aa)
TADA3transcriptional adaptor 3; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (432 aa)
VPS41vacuolar protein sorting 41 homolog (S. cerevisiae); Required for vacuolar assembly and vacuolar traffic (854 aa)
PGA5pepsinogen 5, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (388 aa)
IQSEC3IQ motif and Sec7 domain 3; Acts as a guanine nucleotide exchange factor (GEF) for ARF1 (1182 aa)
BACE1beta-site APP-cleaving enzyme 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (501 aa)
PGA3pepsinogen 3, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (388 aa)
BACE2beta-site APP-cleaving enzyme 2; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672 (518 aa)
CTSEcathepsin E (396 aa)
GBF1golgi brefeldin A resistant guanine nucleotide exchange factor 1; Promotes guanine-nucleotide exchange on ARF5. Promotes the activation of ARF5 through replacement of GDP with GTP (By similarity) (1859 aa)
ARFGEF2ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited); Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extend on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling [...] (1785 aa)
PGCprogastricsin (pepsinogen C); Hydrolyzes a variety of proteins (388 aa)
PGA4pepsinogen 4, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (388 aa)
FBXO8F-box protein 8; May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential) (319 aa)
CYTH2cytohesin 2; Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (399 aa)
ENSG00000250644Uncharacterized protein (379 aa)
ENSG00000268465annotation not available (97 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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