node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B4GALT1 | GALE | ENSP00000369055 | ENSP00000363621 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | 0.900 |
B4GALT1 | GALT | ENSP00000369055 | ENSP00000368119 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | galactose-1-phosphate uridylyltransferase | 0.900 |
B4GALT1 | GLB1 | ENSP00000369055 | ENSP00000306920 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans | 0.912 |
B4GALT1 | LALBA | ENSP00000369055 | ENSP00000301046 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | lactalbumin, alpha-; Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins | 0.955 |
B4GALT1 | LCT | ENSP00000369055 | ENSP00000264162 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | lactase; LPH splits lactose in the small intestine | 0.900 |
B4GALT1 | UBC | ENSP00000369055 | ENSP00000344818 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | ubiquitin C | 0.620 |
CLU | LALBA | ENSP00000315130 | ENSP00000301046 | clusterin; Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress- induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosom [...] | lactalbumin, alpha-; Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins | 0.566 |
CLU | UBC | ENSP00000315130 | ENSP00000344818 | clusterin; Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress- induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosom [...] | ubiquitin C | 0.926 |
CRYAA | LALBA | ENSP00000291554 | ENSP00000301046 | crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions | lactalbumin, alpha-; Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins | 0.576 |
GALE | B4GALT1 | ENSP00000363621 | ENSP00000369055 | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | 0.900 |
GALE | GALT | ENSP00000363621 | ENSP00000368119 | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | galactose-1-phosphate uridylyltransferase | 0.999 |
GALE | LALBA | ENSP00000363621 | ENSP00000301046 | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | lactalbumin, alpha-; Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins | 0.909 |
GALE | LCT | ENSP00000363621 | ENSP00000264162 | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | lactase; LPH splits lactose in the small intestine | 0.422 |
GALE | UBC | ENSP00000363621 | ENSP00000344818 | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | ubiquitin C | 0.893 |
GALT | B4GALT1 | ENSP00000368119 | ENSP00000369055 | galactose-1-phosphate uridylyltransferase | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | 0.900 |
GALT | GALE | ENSP00000368119 | ENSP00000363621 | galactose-1-phosphate uridylyltransferase | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | 0.999 |
GALT | GLB1 | ENSP00000368119 | ENSP00000306920 | galactose-1-phosphate uridylyltransferase | galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans | 0.439 |
GALT | LALBA | ENSP00000368119 | ENSP00000301046 | galactose-1-phosphate uridylyltransferase | lactalbumin, alpha-; Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins | 0.900 |
GALT | UBC | ENSP00000368119 | ENSP00000344818 | galactose-1-phosphate uridylyltransferase | ubiquitin C | 0.431 |
GLB1 | B4GALT1 | ENSP00000306920 | ENSP00000369055 | galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | 0.912 |