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STRINGSTRING
RRP7A RRP7A FCF1 FCF1 EXOSC6 EXOSC6 RPL22L1 RPL22L1 NOC4L NOC4L RPL36AL RPL36AL UTP18 UTP18 PDCD11 PDCD11 RPL9 RPL9 MLL MLL RPL32 RPL32 KRR1 KRR1 RPL8 RPL8 NOP56 NOP56 PELP1 PELP1 RPL35 RPL35 AKT1 AKT1 RPL23 RPL23 RPL36 RPL36 RPL34 RPL34 DHX37 DHX37 RPS14 RPS14 RPLP1 RPLP1 RPL22 RPL22 RPL28 RPL28 RPL41 RPL41
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
UTP18UTP18 small subunit (SSU) processome component homolog (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) (556 aa)
KRR1KRR1, small subunit (SSU) processome component, homolog (yeast); Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity) (381 aa)
RPL36ribosomal protein L36 (105 aa)
RPL35ribosomal protein L35 (123 aa)
RPL8ribosomal protein L8 (257 aa)
AKT1v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] (480 aa)
PELP1proline, glutamate and leucine rich protein 1; Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence- specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth [...] (1274 aa)
RPS14ribosomal protein S14 (151 aa)
DHX37DEAH (Asp-Glu-Ala-His) box polypeptide 37 (1157 aa)
RRP7Aribosomal RNA processing 7 homolog A (S. cerevisiae) (280 aa)
NOC4Lnucleolar complex associated 4 homolog (S. cerevisiae) (516 aa)
FCF1FCF1 small subunit (SSU) processome component homolog (S. cerevisiae); Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly (By similarity) (198 aa)
RPL36ALribosomal protein L36a-like (106 aa)
RPL9ribosomal protein L9 (192 aa)
RPLP1ribosomal protein, large, P1; Plays an important role in the elongation step of protein synthesis (114 aa)
RPL22L1ribosomal protein L22-like 1 (122 aa)
RPL22ribosomal protein L22 (128 aa)
PDCD11programmed cell death 11; Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA (1871 aa)
NOP56NOP56 ribonucleoprotein homolog (yeast); Involved in the early to middle stages of 60S ribosomal subunit biogenesis (594 aa)
RPL23ribosomal protein L23 (140 aa)
RPL34ribosomal protein L34 (117 aa)
RPL32ribosomal protein L32 (135 aa)
EXOSC6exosome component 6; Non-catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ’pervasive’ transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The R [...] (272 aa)
RPL28ribosomal protein L28 (169 aa)
RPL41ribosomal protein L41 (25 aa)
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) (3972 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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