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RLN3 RLN3 TSHB TSHB CRHR1 CRHR1 GPR32 GPR32 GPR150 GPR150 POMC POMC GPR25 GPR25 AVP AVP PTGER4 PTGER4 VIP VIP GHRHR GHRHR SCT SCT RAMP2 RAMP2 IAPP IAPP HRH2 HRH2 NPSR1 NPSR1 GNB1 GNB1 CALCRL CALCRL PTHLH PTHLH GNG12 GNG12 ADCY8 ADCY8 GPR15 GPR15 ADCY3 ADCY3 GNG8 GNG8 GNG7 GNG7 GNB5 GNB5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
SCTsecretin; Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach (121 aa)
IAPPislet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism (89 aa)
RAMP2receptor (G protein-coupled) activity modifying protein 2; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL (175 aa)
TSHBthyroid stimulating hormone, beta; Indispensable for the control of thyroid structure and metabolism (138 aa)
ADCY3adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration (1144 aa)
GNB5guanine nucleotide binding protein (G protein), beta 5; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (395 aa)
POMCproopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol (267 aa)
GPR32G protein-coupled receptor 32; Orphan receptor (356 aa)
GPR15G protein-coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection (360 aa)
ADCY8adenylate cyclase 8 (brain); This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity) (1251 aa)
GNG8guanine nucleotide binding protein (G protein), gamma 8; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (70 aa)
GPR25G protein-coupled receptor 25; Orphan receptor (361 aa)
PTGER4prostaglandin E receptor 4 (subtype EP4); Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function (488 aa)
GHRHRgrowth hormone releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion (423 aa)
NPSR1neuropeptide S receptor 1 (377 aa)
VIPvasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder (170 aa)
GNG12guanine nucleotide binding protein (G protein), gamma 12; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity) (72 aa)
HRH2histamine receptor H2; The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity) (397 aa)
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (340 aa)
GPR150G protein-coupled receptor 150; Orphan receptor (434 aa)
AVParginine vasopressin; Neurophysin 2 specifically binds vasopressin (164 aa)
GNG7guanine nucleotide binding protein (G protein), gamma 7; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striat [...] (68 aa)
CALCRLcalcitonin receptor-like; Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (461 aa)
PTHLHparathyroid hormone-like hormone; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of t [...] (177 aa)
CRHR1corticotropin releasing hormone receptor 1; Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (444 aa)
RLN3relaxin 3; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142) (142 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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