node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BHMT | MTR | ENSP00000274353 | ENSP00000355536 | betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) | 0.611 |
BHMT | MTRR | ENSP00000274353 | ENSP00000264668 | betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state | 0.722 |
MMACHC | MMADHC | ENSP00000383840 | ENSP00000301920 | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12) | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria; Involved in cobalamin metabolism | 0.998 |
MMACHC | MTR | ENSP00000383840 | ENSP00000355536 | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12) | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) | 0.973 |
MMACHC | MTRR | ENSP00000383840 | ENSP00000264668 | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12) | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state | 0.948 |
MMADHC | MMACHC | ENSP00000301920 | ENSP00000383840 | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria; Involved in cobalamin metabolism | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12) | 0.998 |
MMADHC | MTR | ENSP00000301920 | ENSP00000355536 | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria; Involved in cobalamin metabolism | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) | 0.985 |
MMADHC | MTRR | ENSP00000301920 | ENSP00000264668 | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria; Involved in cobalamin metabolism | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state | 0.974 |
MTR | BHMT | ENSP00000355536 | ENSP00000274353 | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) | betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline | 0.611 |
MTR | MMACHC | ENSP00000355536 | ENSP00000383840 | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12) | 0.973 |
MTR | MMADHC | ENSP00000355536 | ENSP00000301920 | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria; Involved in cobalamin metabolism | 0.985 |
MTR | MTRR | ENSP00000355536 | ENSP00000264668 | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state | 0.988 |
MTRR | BHMT | ENSP00000264668 | ENSP00000274353 | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state | betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline | 0.722 |
MTRR | MMACHC | ENSP00000264668 | ENSP00000383840 | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12) | 0.948 |
MTRR | MMADHC | ENSP00000264668 | ENSP00000301920 | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria; Involved in cobalamin metabolism | 0.974 |
MTRR | MTR | ENSP00000264668 | ENSP00000355536 | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) | 0.988 |