node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCR1 | CCR2 | ENSP00000296140 | ENSP00000292301 | chemokine (C-C motif) receptor 1; Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation | chemokine (C-C motif) receptor 2; Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection | 0.903 |
CCR1 | CCR8 | ENSP00000296140 | ENSP00000326432 | chemokine (C-C motif) receptor 1; Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation | chemokine (C-C motif) receptor 8; Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection | 0.905 |
CCR1 | TPST1 | ENSP00000296140 | ENSP00000302413 | chemokine (C-C motif) receptor 1; Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation | tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides | 0.623 |
CCR2 | CCR1 | ENSP00000292301 | ENSP00000296140 | chemokine (C-C motif) receptor 2; Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection | chemokine (C-C motif) receptor 1; Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation | 0.903 |
CCR2 | CCR8 | ENSP00000292301 | ENSP00000326432 | chemokine (C-C motif) receptor 2; Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection | chemokine (C-C motif) receptor 8; Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection | 0.906 |
CCR2 | TPST1 | ENSP00000292301 | ENSP00000302413 | chemokine (C-C motif) receptor 2; Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection | tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides | 0.595 |
CCR8 | CCR1 | ENSP00000326432 | ENSP00000296140 | chemokine (C-C motif) receptor 8; Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection | chemokine (C-C motif) receptor 1; Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation | 0.905 |
CCR8 | CCR2 | ENSP00000326432 | ENSP00000292301 | chemokine (C-C motif) receptor 8; Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection | chemokine (C-C motif) receptor 2; Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection | 0.906 |
CCR8 | TPST1 | ENSP00000326432 | ENSP00000302413 | chemokine (C-C motif) receptor 8; Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection | tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides | 0.586 |
CMKLR1 | TPST1 | ENSP00000311733 | ENSP00000302413 | chemokine-like receptor 1; Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239 [...] | tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides | 0.573 |
GP1BA | TPST1 | ENSP00000329380 | ENSP00000302413 | glycoprotein Ib (platelet), alpha polypeptide; GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium | tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides | 0.598 |
GPR1 | TPST1 | ENSP00000384345 | ENSP00000302413 | G protein-coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1 | tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides | 0.573 |
SELPLG | TPST1 | ENSP00000228463 | ENSP00000302413 | selectin P ligand; A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture | tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides | 0.696 |
TPST1 | CCR1 | ENSP00000302413 | ENSP00000296140 | tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides | chemokine (C-C motif) receptor 1; Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation | 0.623 |
TPST1 | CCR2 | ENSP00000302413 | ENSP00000292301 | tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides | chemokine (C-C motif) receptor 2; Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection | 0.595 |
TPST1 | CCR8 | ENSP00000302413 | ENSP00000326432 | tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides | chemokine (C-C motif) receptor 8; Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection | 0.586 |
TPST1 | CMKLR1 | ENSP00000302413 | ENSP00000311733 | tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides | chemokine-like receptor 1; Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239 [...] | 0.573 |
TPST1 | GP1BA | ENSP00000302413 | ENSP00000329380 | tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides | glycoprotein Ib (platelet), alpha polypeptide; GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium | 0.598 |
TPST1 | GPR1 | ENSP00000302413 | ENSP00000384345 | tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides | G protein-coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1 | 0.573 |
TPST1 | SELPLG | ENSP00000302413 | ENSP00000228463 | tyrosylprotein sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides | selectin P ligand; A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture | 0.696 |