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DYNLRB2 DYNLRB2 DYNLRB1 DYNLRB1 DYNLL1 DYNLL1 DYNLL2 DYNLL2 TCTE3 TCTE3 TCTEX1D1 TCTEX1D1 DYNC2LI1 DYNC2LI1 KIF17 KIF17 KIFAP3 KIFAP3 IFT81 IFT81 IFT88 IFT88 IFT122 IFT122 KIF3C KIF3C IFT74 IFT74 TTC21B TTC21B IFT172 IFT172 IFT52 IFT52 IFT43 IFT43 WDR19 WDR19 TRAF3IP1 TRAF3IP1 RABL5 RABL5 IFT80 IFT80 CLUAP1 CLUAP1 IFT20 IFT20 TTC30B TTC30B TTC30A TTC30A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
IFT43intraflagellar transport 43 homolog (Chlamydomonas); Component of IFT complex A (IFT-A) involved in retrograde ciliary transport along microtubules from the ciliary tip to the base (213 aa)
DYNLL2dynein, light chain, LC8-type 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity) (89 aa)
DYNLL1dynein, light chain, LC8-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (89 aa)
IFT81intraflagellar transport 81 homolog (Chlamydomonas); Isoform CDV-1 may be involved in cardiac hypertrophy caused by carnitine deficiency (By similarity) (676 aa)
TTC21Btetratricopeptide repeat domain 21B (1316 aa)
KIF17kinesin family member 17; Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules (By similarity) (1029 aa)
IFT172intraflagellar transport 172 homolog (Chlamydomonas); Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity) (1749 aa)
DYNC2LI1dynein, cytoplasmic 2, light intermediate chain 1 (351 aa)
KIF3Ckinesin family member 3C; Microtubule-based anterograde translocator for membranous organelles (By similarity) (793 aa)
TCTEX1D1Tctex1 domain containing 1 (179 aa)
IFT122intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) (1292 aa)
DYNLRB2dynein, light chain, roadblock-type 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (96 aa)
IFT80intraflagellar transport 80 homolog (Chlamydomonas); Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia (777 aa)
RABL5RAB, member RAS oncogene family-like 5 (185 aa)
IFT88intraflagellar transport 88 homolog (Chlamydomonas); Involved in primary cilium biogenesis (By similarity) (833 aa)
TTC30Atetratricopeptide repeat domain 30A; Required for polyglutamylation of axonemal tubulin (By similarity). Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity) (665 aa)
DYNLRB1dynein, light chain, roadblock-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (96 aa)
IFT20intraflagellar transport 20 homolog (Chlamydomonas); Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium (148 aa)
KIFAP3kinesin-associated protein 3; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity) (792 aa)
TCTE3t-complex-associated-testis-expressed 3; May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in male sterility (By similarity) (198 aa)
IFT52intraflagellar transport 52 homolog (Chlamydomonas) (437 aa)
TRAF3IP1TNF receptor-associated factor 3 interacting protein 1; Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules (691 aa)
IFT74intraflagellar transport 74 homolog (Chlamydomonas) (600 aa)
WDR19WD repeat domain 19; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Involved in cilia function and/or assembly (By similarity) (1342 aa)
TTC30Btetratricopeptide repeat domain 30B; Required for polyglutamylation of axonemal tubulin (By similarity). Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity) (665 aa)
CLUAP1clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity) (413 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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