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GINS4 GINS4 CYB5A CYB5A CYB5B CYB5B ALDH8A1 ALDH8A1 CYB5R4 CYB5R4 ALDH7A1 ALDH7A1 RRM1 RRM1 ALDH5A1 ALDH5A1 ALDH1L2 ALDH1L2 ALDH1A1 ALDH1A1 HK1 HK1 ALDH1B1 ALDH1B1 HK3 HK3 UBC UBC GCK GCK HK2 HK2 HKDC1 HKDC1 ALDH3B2 ALDH3B2 ALDH3A1 ALDH3A1 UBXN2B UBXN2B TDRD1 TDRD1 ALDH2 ALDH2 GSTZ1 GSTZ1 ENSG00000257767 ENSG00000257767 VAT1L VAT1L ENSG00000269469 ENSG00000269469
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
GSTZ1glutathione S-transferase zeta 1 (216 aa)
GCKglucokinase (hexokinase 4); Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage (466 aa)
ALDH3A1aldehyde dehydrogenase 3 family, member A1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes (453 aa)
TDRD1tudor domain containing 1 (1189 aa)
ALDH3B2aldehyde dehydrogenase 3 family, member B2 (385 aa)
ALDH1L2aldehyde dehydrogenase 1 family, member L2 (923 aa)
ALDH2aldehyde dehydrogenase 2 family (mitochondrial) (517 aa)
ALDH8A1aldehyde dehydrogenase 8 family, member A1; Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro) (487 aa)
GINS4GINS complex subunit 4 (Sld5 homolog); The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA (223 aa)
HK2hexokinase 2 (917 aa)
HK3hexokinase 3 (white cell) (923 aa)
ALDH1A1aldehyde dehydrogenase 1 family, member A1; Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity) (501 aa)
RRM1ribonucleotide reductase M1; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) (792 aa)
VAT1Lvesicle amine transport protein 1 homolog (T. californica)-like (419 aa)
CYB5Bcytochrome b5 type B (outer mitochondrial membrane); Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases (By similarity) (150 aa)
ALDH5A1aldehyde dehydrogenase 5 family, member A1; Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) (548 aa)
CYB5Acytochrome b5 type A (microsomal); Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases (134 aa)
UBCubiquitin C (685 aa)
HKDC1hexokinase domain containing 1 (917 aa)
CYB5R4cytochrome b5 reductase 4; NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin (521 aa)
ALDH1B1aldehyde dehydrogenase 1 family, member B1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (517 aa)
UBXN2BUBX domain protein 2B; Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity (331 aa)
HK1hexokinase 1 (921 aa)
ALDH7A1aldehyde dehydrogenase 7 family, member A1; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (539 aa)
ENSG00000257767Uncharacterized protein (245 aa)
ENSG00000269469Uncharacterized protein (72 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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