Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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 | WASL | Wiskott-Aldrich syndrome-like; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (505 aa) | ||
 | RPS12 | ribosomal protein S12 (132 aa) | ||
 | WDFY1 | WD repeat and FYVE domain containing 1 (410 aa) | ||
 | HSPB1 | heat shock 27kDa protein 1 (205 aa) | ||
 | SHFM1 | split hand/foot malformation (ectrodactyly) type 1; Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis (70 aa) | ||
 | HIP1R | huntingtin interacting protein 1 related; Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (1068 aa) | ||
 | DDB2 | damage-specific DNA binding protein 2, 48kDa; Required for DNA repair. Binds to DDB1 to form the UV- damaged DNA-binding protein complex (the UV-DDB complex). The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1- CUL4-X-box) E3 ubiquitin-protein ligase complex [...] (427 aa) | ||
 | WDR59 | WD repeat domain 59 (974 aa) | ||
 | SSBP1 | single-stranded DNA binding protein 1, mitochondrial; This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication. Associates with mitochondrial DNA (148 aa) | ||
 | DMWD | dystrophia myotonica, WD repeat containing; Could have a regulatory function in meiosis (674 aa) | ||
 | IFT122 | intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) (1292 aa) | ||
 | WDFY2 | WD repeat and FYVE domain containing 2 (400 aa) | ||
 | USP38 | ubiquitin specific peptidase 38; Deubiquitinating enzyme exhibiting a preference towards ’Lys-63’-linked Ubiquitin chains (1042 aa) | ||
 | TBL2 | transducin (beta)-like 2 (447 aa) | ||
 | WDR48 | WD repeat domain 48 (677 aa) | ||
 | C22orf25 | chromosome 22 open reading frame 25 (276 aa) | ||
 | HIP1 | huntingtin interacting protein 1 (1037 aa) | ||
 | RPL7 | ribosomal protein L7; Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (248 aa) | ||
 | HMX2 | H6 family homeobox 2; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development (By similarity) (273 aa) | ||
 | UBC | ubiquitin C (685 aa) | ||
 | HMX3 | H6 family homeobox 3; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5’-CAAGTG-3’ core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS (By similarity) (357 aa) | ||
 | VAV2 | vav 2 guanine nucleotide exchange factor (878 aa) | ||
 | WAS | Wiskott-Aldrich syndrome; Effector protein for Rho-type GTPases. Regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (502 aa) | ||
 | LGALS7 | lectin, galactoside-binding, soluble, 7; Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release (136 aa) | ||
 | WDR20 | WD repeat domain 20 (600 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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