node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADPRM | NUDT5 | ENSP00000369099 | ENSP00000419628 | ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent; Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP- choline and CDP-ethanolamine, but not other non-reducing ADP- sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity) | nudix (nucleoside diphosphate linked moiety X)-type motif 5; Hydrolyzes with similar activities ADP-ribose ADP- mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA | 0.876 |
ADPRM | NUDT9 | ENSP00000369099 | ENSP00000303575 | ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent; Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP- choline and CDP-ethanolamine, but not other non-reducing ADP- sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity) | nudix (nucleoside diphosphate linked moiety X)-type motif 9; Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5’- phosphate | 0.800 |
ADPRM | PGM1 | ENSP00000369099 | ENSP00000360124 | ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent; Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP- choline and CDP-ethanolamine, but not other non-reducing ADP- sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity) | phosphoglucomutase 1 | 0.900 |
ADPRM | PGM2 | ENSP00000369099 | ENSP00000371393 | ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent; Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP- choline and CDP-ethanolamine, but not other non-reducing ADP- sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity) | phosphoglucomutase 2; Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. May also catalyze the interconversion of glucose-1-phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity | 0.900 |
ADPRM | PRPS1L1 | ENSP00000369099 | ENSP00000424595 | ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent; Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP- choline and CDP-ethanolamine, but not other non-reducing ADP- sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity) | phosphoribosyl pyrophosphate synthetase 1-like 1; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis | 0.900 |
ADPRM | PRPS2 | ENSP00000369099 | ENSP00000381504 | ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent; Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP- choline and CDP-ethanolamine, but not other non-reducing ADP- sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity) | phosphoribosyl pyrophosphate synthetase 2; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis | 0.932 |
GLOD4 | NUDT9 | ENSP00000301329 | ENSP00000303575 | glyoxalase domain containing 4 | nudix (nucleoside diphosphate linked moiety X)-type motif 9; Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5’- phosphate | 0.628 |
IMPA1 | IMPA2 | ENSP00000408526 | ENSP00000269159 | inositol(myo)-1(or 4)-monophosphatase 1; Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol- phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1- phosphate, beta-glycerophosphate, and 2’-AMP as substrates | inositol(myo)-1(or 4)-monophosphatase 2; Can use myo-inositol monophosphates, scylloinositol 1,4- diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2’- AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain | 0.961 |
IMPA2 | IMPA1 | ENSP00000269159 | ENSP00000408526 | inositol(myo)-1(or 4)-monophosphatase 2; Can use myo-inositol monophosphates, scylloinositol 1,4- diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2’- AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain | inositol(myo)-1(or 4)-monophosphatase 1; Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol- phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1- phosphate, beta-glycerophosphate, and 2’-AMP as substrates | 0.961 |
NUDT5 | ADPRM | ENSP00000419628 | ENSP00000369099 | nudix (nucleoside diphosphate linked moiety X)-type motif 5; Hydrolyzes with similar activities ADP-ribose ADP- mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA | ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent; Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP- choline and CDP-ethanolamine, but not other non-reducing ADP- sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity) | 0.876 |
NUDT5 | NUDT9 | ENSP00000419628 | ENSP00000303575 | nudix (nucleoside diphosphate linked moiety X)-type motif 5; Hydrolyzes with similar activities ADP-ribose ADP- mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA | nudix (nucleoside diphosphate linked moiety X)-type motif 9; Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5’- phosphate | 0.936 |
NUDT5 | PGM1 | ENSP00000419628 | ENSP00000360124 | nudix (nucleoside diphosphate linked moiety X)-type motif 5; Hydrolyzes with similar activities ADP-ribose ADP- mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA | phosphoglucomutase 1 | 0.900 |
NUDT5 | PGM2 | ENSP00000419628 | ENSP00000371393 | nudix (nucleoside diphosphate linked moiety X)-type motif 5; Hydrolyzes with similar activities ADP-ribose ADP- mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA | phosphoglucomutase 2; Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. May also catalyze the interconversion of glucose-1-phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity | 0.904 |
NUDT5 | PRPS1L1 | ENSP00000419628 | ENSP00000424595 | nudix (nucleoside diphosphate linked moiety X)-type motif 5; Hydrolyzes with similar activities ADP-ribose ADP- mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA | phosphoribosyl pyrophosphate synthetase 1-like 1; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis | 0.909 |
NUDT5 | PRPS2 | ENSP00000419628 | ENSP00000381504 | nudix (nucleoside diphosphate linked moiety X)-type motif 5; Hydrolyzes with similar activities ADP-ribose ADP- mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA | phosphoribosyl pyrophosphate synthetase 2; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis | 0.942 |
NUDT9 | ADPRM | ENSP00000303575 | ENSP00000369099 | nudix (nucleoside diphosphate linked moiety X)-type motif 9; Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5’- phosphate | ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent; Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP- choline and CDP-ethanolamine, but not other non-reducing ADP- sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity) | 0.800 |
NUDT9 | GLOD4 | ENSP00000303575 | ENSP00000301329 | nudix (nucleoside diphosphate linked moiety X)-type motif 9; Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5’- phosphate | glyoxalase domain containing 4 | 0.628 |
NUDT9 | NUDT5 | ENSP00000303575 | ENSP00000419628 | nudix (nucleoside diphosphate linked moiety X)-type motif 9; Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5’- phosphate | nudix (nucleoside diphosphate linked moiety X)-type motif 5; Hydrolyzes with similar activities ADP-ribose ADP- mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA | 0.936 |
NUDT9 | PGM1 | ENSP00000303575 | ENSP00000360124 | nudix (nucleoside diphosphate linked moiety X)-type motif 9; Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5’- phosphate | phosphoglucomutase 1 | 0.900 |
NUDT9 | PGM2 | ENSP00000303575 | ENSP00000371393 | nudix (nucleoside diphosphate linked moiety X)-type motif 9; Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5’- phosphate | phosphoglucomutase 2; Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. May also catalyze the interconversion of glucose-1-phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity | 0.900 |