7 items (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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protein of unknown 3D structure

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	DNAJC10	DnaJ (Hsp40) homolog, subfamily C, member 10 (793 aa)
	MZB1	marginal zone B and B1 cell-specific protein; Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation (189 aa)
	CASP2	caspase 2, apoptosis-related cysteine peptidase (452 aa)
	HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER (654 aa)
	CASP9	caspase 9, apoptosis-related cysteine peptidase (416 aa)
	UBC	ubiquitin C (685 aa)
	HYOU1	hypoxia up-regulated 1; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding (999 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP2	CASP9	ENSP00000312664	ENSP00000330237	caspase 2, apoptosis-related cysteine peptidase	caspase 9, apoptosis-related cysteine peptidase	0.663
CASP2	MZB1	ENSP00000312664	ENSP00000303920	caspase 2, apoptosis-related cysteine peptidase	marginal zone B and B1 cell-specific protein; Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation	0.976
CASP2	UBC	ENSP00000312664	ENSP00000344818	caspase 2, apoptosis-related cysteine peptidase	ubiquitin C	0.491
CASP9	CASP2	ENSP00000330237	ENSP00000312664	caspase 9, apoptosis-related cysteine peptidase	caspase 2, apoptosis-related cysteine peptidase	0.663
CASP9	HSPA5	ENSP00000330237	ENSP00000324173	caspase 9, apoptosis-related cysteine peptidase	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER	0.431
CASP9	MZB1	ENSP00000330237	ENSP00000303920	caspase 9, apoptosis-related cysteine peptidase	marginal zone B and B1 cell-specific protein; Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation	0.815
CASP9	UBC	ENSP00000330237	ENSP00000344818	caspase 9, apoptosis-related cysteine peptidase	ubiquitin C	0.816
DNAJC10	HSPA5	ENSP00000264065	ENSP00000324173	DnaJ (Hsp40) homolog, subfamily C, member 10	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER	0.999
DNAJC10	HYOU1	ENSP00000264065	ENSP00000384144	DnaJ (Hsp40) homolog, subfamily C, member 10	hypoxia up-regulated 1; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding	0.946
DNAJC10	MZB1	ENSP00000264065	ENSP00000303920	DnaJ (Hsp40) homolog, subfamily C, member 10	marginal zone B and B1 cell-specific protein; Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation	0.756
DNAJC10	UBC	ENSP00000264065	ENSP00000344818	DnaJ (Hsp40) homolog, subfamily C, member 10	ubiquitin C	0.821
HSPA5	CASP9	ENSP00000324173	ENSP00000330237	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER	caspase 9, apoptosis-related cysteine peptidase	0.431
HSPA5	DNAJC10	ENSP00000324173	ENSP00000264065	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER	DnaJ (Hsp40) homolog, subfamily C, member 10	0.999
HSPA5	HYOU1	ENSP00000324173	ENSP00000384144	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER	hypoxia up-regulated 1; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding	0.877
HSPA5	MZB1	ENSP00000324173	ENSP00000303920	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER	marginal zone B and B1 cell-specific protein; Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation	0.751
HSPA5	UBC	ENSP00000324173	ENSP00000344818	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER	ubiquitin C	0.999
HYOU1	DNAJC10	ENSP00000384144	ENSP00000264065	hypoxia up-regulated 1; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding	DnaJ (Hsp40) homolog, subfamily C, member 10	0.946
HYOU1	HSPA5	ENSP00000384144	ENSP00000324173	hypoxia up-regulated 1; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER	0.877
MZB1	CASP2	ENSP00000303920	ENSP00000312664	marginal zone B and B1 cell-specific protein; Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation	caspase 2, apoptosis-related cysteine peptidase	0.976
MZB1	CASP9	ENSP00000303920	ENSP00000330237	marginal zone B and B1 cell-specific protein; Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation	caspase 9, apoptosis-related cysteine peptidase	0.815

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