| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATP6V1E1 | TMEM43 | ENSP00000253413 | ENSP00000303992 | ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells | transmembrane protein 43; May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity) | 0.644 |
| ATP6V1E1 | UBC | ENSP00000253413 | ENSP00000344818 | ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells | ubiquitin C | 0.756 |
| DDX28 | TMEM43 | ENSP00000332340 | ENSP00000303992 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 28; May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity | transmembrane protein 43; May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity) | 0.644 |
| EIF4A1 | SRSF1 | ENSP00000293831 | ENSP00000258962 | eukaryotic translation initiation factor 4A1; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5’-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon | serine/arginine-rich splicing factor 1; Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5’- and 3’-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5’-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5’-RGAAGAAC-3’ (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5’- CGAGGCG-3’ motif in vitro. Three copies of the octame [...] | 0.526 |
| EIF4A1 | TMEM43 | ENSP00000293831 | ENSP00000303992 | eukaryotic translation initiation factor 4A1; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5’-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon | transmembrane protein 43; May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity) | 0.644 |
| EIF4A1 | UBC | ENSP00000293831 | ENSP00000344818 | eukaryotic translation initiation factor 4A1; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5’-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon | ubiquitin C | 0.997 |
| GPRASP2 | TMEM43 | ENSP00000339057 | ENSP00000303992 | G protein-coupled receptor associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors | transmembrane protein 43; May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity) | 0.481 |
| MCAT | TMEM43 | ENSP00000290429 | ENSP00000303992 | malonyl CoA-ACP acyltransferase (mitochondrial); Catalyzes the transfer of a malonyl moiety from malonyl- CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondrias | transmembrane protein 43; May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity) | 0.644 |
| MCAT | UBC | ENSP00000290429 | ENSP00000344818 | malonyl CoA-ACP acyltransferase (mitochondrial); Catalyzes the transfer of a malonyl moiety from malonyl- CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondrias | ubiquitin C | 0.478 |
| MMS19 | UBC | ENSP00000359818 | ENSP00000344818 | MMS19 nucleotide excision repair homolog (S. cerevisiae) | ubiquitin C | 0.901 |
| MRPS5 | TMEM43 | ENSP00000272418 | ENSP00000303992 | mitochondrial ribosomal protein S5 | transmembrane protein 43; May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity) | 0.893 |
| MRPS5 | UBC | ENSP00000272418 | ENSP00000344818 | mitochondrial ribosomal protein S5 | ubiquitin C | 0.761 |
| MRPS5 | ZMPSTE24 | ENSP00000272418 | ENSP00000361845 | mitochondrial ribosomal protein S5 | zinc metallopeptidase STE24 homolog (S. cerevisiae); Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C | 0.914 |
| SIAH1 | UBC | ENSP00000349156 | ENSP00000344818 | siah E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcriptio [...] | ubiquitin C | 0.987 |
| SLC12A4 | TMEM43 | ENSP00000395983 | ENSP00000303992 | solute carrier family 12 (potassium/chloride transporters), member 4 | transmembrane protein 43; May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity) | 0.644 |
| SLC12A4 | UBC | ENSP00000395983 | ENSP00000344818 | solute carrier family 12 (potassium/chloride transporters), member 4 | ubiquitin C | 0.906 |
| SRSF1 | EIF4A1 | ENSP00000258962 | ENSP00000293831 | serine/arginine-rich splicing factor 1; Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5’- and 3’-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5’-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5’-RGAAGAAC-3’ (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5’- CGAGGCG-3’ motif in vitro. Three copies of the octame [...] | eukaryotic translation initiation factor 4A1; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5’-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon | 0.526 |
| SRSF1 | TMEM43 | ENSP00000258962 | ENSP00000303992 | serine/arginine-rich splicing factor 1; Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5’- and 3’-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5’-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5’-RGAAGAAC-3’ (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5’- CGAGGCG-3’ motif in vitro. Three copies of the octame [...] | transmembrane protein 43; May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity) | 0.644 |
| SRSF1 | UBC | ENSP00000258962 | ENSP00000344818 | serine/arginine-rich splicing factor 1; Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5’- and 3’-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5’-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5’-RGAAGAAC-3’ (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5’- CGAGGCG-3’ motif in vitro. Three copies of the octame [...] | ubiquitin C | 0.987 |
| TMEM43 | ATP6V1E1 | ENSP00000303992 | ENSP00000253413 | transmembrane protein 43; May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity) | ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells | 0.644 |
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